Rabbit RORC / ROR Gamma Polyclonal Antibody | anti-RORC antibody

Rabbit Polyclonal to Human RORC / ROR Gamma

Cat. Num. AAA244262

• Gene Names: RORC; TOR; RORG; RZRG; NR1F3; RZR-GAMMA
• Reactivity: Gibbon, Chimpanzee, Gorilla, Human, Monkey, Orangutan; Predicted Reactivity: Bat, Bovine, Dog, Horse, Rabbit (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: RORC / ROR Gamma; Polyclonal Antibody; Rabbit Polyclonal to Human RORC / ROR Gamma; Anti-RORC / ROR Gamma Antibody (Ligand-binding Domain) IHC-plus; RORC; Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; RAR-related orphan receptor C; RORG; RORgamma; TOR; ROR Gamma; RZRG; NR1F3; RZR-GAMMA; Human RORC; anti-RORC antibody

• Host: Rabbit
• Reactivity: Gibbon, Chimpanzee, Gorilla, Human, Monkey, Orangutan; Predicted Reactivity: Bat, Bovine, Dog, Horse, Rabbit (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human ROR Gamma. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except RORA (56%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 518

• Applicable Applications for anti-RORC antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA, IHC-P (15 - 20 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 16 amino acid peptide from ligand-binding domain of human ROR Gamma. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Tamarin, Opossum (100%).
• Immunogen Type: Synthetic peptide
• Immunogen: RORC / ROR Gamma antibody was raised against synthetic 16 amino acid peptide from ligand-binding domain of human ROR Gamma. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Tamarin, Opossum (100%); Elephant, Panda, Bovine, Bat, Dog, Horse, Rabbit (94%); Mouse, Rat, Hamster (88%).
• Antigen Modification: Ligand-binding Domain
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-ROR Gamma antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-RORC antibody

ROR Gamma (RORC), an NR1 Thyroid Hormone-Like receptor, has been shown to affect thymopoiesis, bone metabolism, T-cell apoptosis, and lymphoid organogenesis. ROR gamma has been shown to promote thymocyte survival by activating the expression of the antiapoptotic protein Bcl-x(L). ROR gamma is also required for the development of lymph nodes and Peyer's patches.

Product Categories/Family for anti-RORC antibody

Family: NHR; Subfamily: NR1 Thyroid hormone-like

NCBI and Uniprot Product Information

• NCBI GI #: 19743909
• NCBI GeneID: 6097
• NCBI Accession #: NP_005051.2
• NCBI GenBank Nucleotide #: NM_005060.3
• UniProt Accession #: P51449; Q5SZR9; Q8N5V7; Q8NCY8
• Molecular Weight: 55,813 Da
• NCBI Official Full Name: nuclear receptor ROR-gamma isoform a
• NCBI Official Synonym Full Names: RAR-related orphan receptor C
• NCBI Official Symbol: RORC
• NCBI Official Synonym Symbols: TOR; RORG; RZRG; NR1F3; RZR-GAMMA
• NCBI Protein Information: nuclear receptor ROR-gamma; nuclear receptor RZR-gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; RAR-related orphan receptor C, isoform a; RAR-related orphan nuclear receptor variant 2; nuclear receptor subfamily 1 group F member 3
• UniProt Protein Name: Nuclear receptor ROR-gamma
• Protein Family: Nuclear receptor
• UniProt Gene Name: RORC
• UniProt Synonym Gene Names: NR1F3; RORG; RZRG
• UniProt Entry Name: RORG_HUMAN

NCBI Description

The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

RORC: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor activity; DNA binding; zinc ion binding; sequence-specific DNA binding; oxysterol binding; steroid hormone receptor activity; transcription factor activity

Biological Process: Peyer's patch development; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; T-helper cell differentiation; regulation of fat cell differentiation; positive regulation of transcription, DNA-dependent; T cell differentiation in the thymus; positive regulation of circadian rhythm; protein amino acid phosphorylation; regulation of gamma-delta T cell differentiation; lymph node development; xenobiotic metabolic process; regulation of steroid metabolic process; steroid hormone mediated signaling; gene expression; circadian regulation of gene expression