Rabbit RNASEH2B Polyclonal Antibody | anti-RNASEH2B antibody

RNASEH2B Rabbit Polyclonal

Cat. Num. AAA7603562

• Gene Names: RNASEH2B; AGS2; DLEU8
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: RNASEH2B; Polyclonal Antibody; RNASEH2B Rabbit Polyclonal; anti-RNASEH2B antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 257

• Applicable Applications for anti-RNASEH2B antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Ribonuclease H2, subunit B
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(mouse thymus tissue were subjected to SDS PAGE followed by western blot with MBS7603562 (RNASEH2B antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 214010191
• NCBI GeneID: 79621
• NCBI Accession #: NP_001135751.1
• NCBI GenBank Nucleotide #: NM_001142279.2
• Molecular Weight: 29,005 Da
• NCBI Official Full Name: ribonuclease H2 subunit B isoform 2
• NCBI Official Synonym Full Names: ribonuclease H2 subunit B
• NCBI Official Symbol: RNASEH2B
• NCBI Official Synonym Symbols: AGS2; DLEU8
• NCBI Protein Information: ribonuclease H2 subunit B
• UniProt Protein Name: Ribonuclease H2 subunit B
• Protein Family: Ribonuclease
• UniProt Gene Name: RNASEH2B
• UniProt Synonym Gene Names: DLEU8; RNase H2 subunit B; AGS2
• UniProt Entry Name: RNH2B_HUMAN

NCBI Description

RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]

Uniprot Description

RNASEH2B: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2B are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood. Belongs to the RNase H2 subunit B family.

Protein type: RNA processing; DNA replication

Chromosomal Location of Human Ortholog: 13q14.3

Cellular Component: nucleus

Molecular Function: ribonuclease H activity

Biological Process: in utero embryonic development; positive regulation of fibroblast proliferation; regulation of G2/M transition of mitotic cell cycle; ribonucleotide metabolic process; RNA catabolic process

Disease: Aicardi-goutieres Syndrome 2