Rabbit anti-Human, Mouse RMND5B Polyclonal Antibody | anti-RMND5B antibody

RMND5B Antibody

Cat. Num. AAA9631079

• Gene Names: RMND5B; GID2; GID2B
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: RMND5B; Polyclonal Antibody; RMND5B Antibody; FLJ22318; MGC112682; Protein RMD5 homolog B; Required for meiotic nuclear division 5 homolog B (S. cerevisiae); RP23-79E13.4; anti-RMND5B antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: RMND5B Antibody detects endogenous levels of RMND5B.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-RMND5B antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human RMND5B.
• Conjugation: Unconjugated
• Subunit Structure: Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles.
• Function: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-RMND5B antibody

Cytoplasm; Cytosol; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 571031354
• NCBI GeneID: 64777
• NCBI Accession #: NP_001275723.1
• NCBI GenBank Nucleotide #: NM_001288794.1
• UniProt Accession #: Q96G75; Q1HE27; Q6UVY7; Q9H6F6
• Molecular Weight: 44,414 Da
• NCBI Official Full Name: protein RMD5 homolog B isoform a
• NCBI Official Synonym Full Names: required for meiotic nuclear division 5 homolog B (S. cerevisiae)
• NCBI Official Symbol: RMND5B
• NCBI Official Synonym Symbols: GID2; GID2B
• NCBI Protein Information: protein RMD5 homolog B; GID complex subunit 2 homolog B
• UniProt Protein Name: Protein RMD5 homolog B
• Protein Family: Protein
• UniProt Gene Name: RMND5B
• UniProt Synonym Gene Names: UNQ2508/PRO5996
• UniProt Entry Name: RMD5B_HUMAN