Rabbit anti-Human RLN2 Polyclonal Antibody | anti-RLN2 antibody

RLN2, CT (RLN2, Prorelaxin H2, Relaxin B chain, Relaxin A chain)

Cat. Num. AAA649096

• Gene Names: RLN2; H2; RLXH2; H2-RLX; bA12D24.1.1; bA12D24.1.2
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: RLN2; Polyclonal Antibody; CT (RLN2; Prorelaxin H2; Relaxin B chain; Relaxin A chain); Anti -RLN2; anti-RLN2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-RLN2 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: RLN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-165 amino acids from the C-terminal region of human RLN2.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(RLN2 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the RLN2 antibody detected the RLN2 protein (arrow).)

Related Product Information for anti-RLN2 antibody

Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.

Product Categories/Family for anti-RLN2 antibody

Antibodies; Abs to Spermatogenesis; Testis Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 119579175
• NCBI GeneID: 6019
• UniProt Accession #: P04090; Q99936; Q9UCX3; Q9UQJ2; A0AVM0
• Molecular Weight: 21,043 Da
• NCBI Official Full Name: relaxin 2, isoform CRA_b
• NCBI Official Synonym Full Names: relaxin 2
• NCBI Official Symbol: RLN2
• NCBI Official Synonym Symbols: H2; RLXH2; H2-RLX; bA12D24.1.1; bA12D24.1.2
• NCBI Protein Information: prorelaxin H2; H2-preprorelaxin; relaxin, ovarian, of pregnancy
• UniProt Protein Name: Prorelaxin H2
• Protein Family: Prorelaxin
• UniProt Gene Name: RLN2
• UniProt Entry Name: REL2_HUMAN

NCBI Description

Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The active form of the protein encoded by this gene consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Uniprot Description

Function: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.

Subunit structure: Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Subcellular location: Secreted.

Tissue specificity: Isoform 1 is expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 is relatively abundant in placenta. It is in much lower abundance in the prostate gland. Not detected in the ovary. Ref.1 Ref.4

Sequence similarities: Belongs to the insulin family.