Rabbit anti-Human RLN1/RLN2 Polyclonal Antibody | anti-RLN1 antibody

RLN1/RLN2 Antibody (C-term)

Cat. Num. AAA9212031

• Gene Names: RLN1; H1; H1RLX; RLXH1; bA12D24.3.1; bA12D24.3.2
• Reactivity: Human
• Applications: Western Blot, ELISA, Immunohistochemistry
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: RLN1/RLN2; Polyclonal Antibody; RLN1/RLN2 Antibody (C-term); Prorelaxin H1; Relaxin B chain; Relaxin A chain; RLN1; anti-RLN1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This RLN1/RLN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-165 amino acids from the C-terminal region of human RLN1/RLN2.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.4 (varies by lot)
• Sequence Positions: 136-165
• Sequence Length: 185

• Applicable Applications for anti-RLN1 antibody: Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: WB~~1:1000
• Antigen Type: Synthetic Peptide
• Antigen Source: HUMAN
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(RLN1/RLN2 Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the RLN1/RLN2 antibody detected the RLN1/RLN2 protein (arrow).)

Immunohistochemistry (IHC)

(RLN1/RLN2 Antibody (C-term) (MBS9212031)immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RLN1/RLN2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-RLN1 antibody

Relaxins are known endocrine and autocrine/paracrine
hormones, belonging to the insulin gene superfamily. In the human
there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3.
RLN1 and RLN2 share high sequence homology. This encoded protein is
synthesized as a single-chain polypeptide but the active form
consists of an A chain and a B chain linked by disulfide bonds;
however, their exact cleavage sites have not been described.
Relaxin is produced by the ovary, and targets the mammalian
reproductive system to ripen the cervix, elongate the pubic
symphysis and inhibit uterine contraction. It may have additional
roles in enhancing sperm motility, regulating blood pressure,
controlling heart rate and releasing oxytocin and vasopressin. This
gene has multiple polyadenylation sites. There are multiple
alternatively spliced transcript variants described for this gene
but their full length nature is not known yet. [provided by
RefSeq].

Product Categories/Family for anti-RLN1 antibody

Cardiovascular; Neuroscience; Signal Transduction

References

Radestock, Y., et al. Mol. Cancer Res. 8(4):494-506(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Ferlin, A., et al. Bone 46(2):504-513(2010)
Vogel, I., et al. In Vivo 23(6):1005-1009(2009)
Anumba, D.O., et al. Eur. J. Obstet. Gynecol. Reprod. Biol. 147(1):41-45(2009)

NCBI and Uniprot Product Information

• NCBI GI #: 5902052
• NCBI GeneID: 6013
• NCBI Accession #: NP_008842.1
• NCBI GenBank Nucleotide #: NM_006911.3
• UniProt Accession #: P04808; Q99936; Q9UQJ1
• Molecular Weight: 21146
• NCBI Official Full Name: prorelaxin H1 preproprotein
• NCBI Official Synonym Full Names: relaxin 1
• NCBI Official Symbol: RLN1
• NCBI Official Synonym Symbols: H1; H1RLX; RLXH1; bA12D24.3.1; bA12D24.3.2
• NCBI Protein Information: prorelaxin H1
• UniProt Protein Name: Prorelaxin H1
• Protein Family: Prorelaxin
• UniProt Gene Name: RLN1
• UniProt Entry Name: REL1_HUMAN

NCBI Description

Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]

Uniprot Description

RLN1: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Belongs to the insulin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: extracellular region

Molecular Function: hormone activity

Biological Process: female pregnancy; signal transduction