Rabbit anti-Human, Mouse RIO Kinase 3 Polyclonal Antibody | anti-RIOK3 antibody

RIO Kinase 3 (RIOK3, Serine/threonine-protein Kinase RIO3, SudD Homolog, SUDD) (FITC)

Cat. Num. AAA6392598

• Gene Names: RIOK3; SUDD
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: RIO Kinase 3; Polyclonal Antibody; RIO Kinase 3 (RIOK3; Serine/threonine-protein Kinase RIO3; SudD Homolog; SUDD) (FITC); EC=2.7.11.1; DKFZp779L1370; anti-RIOK3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human RIOK3. Species Crossreactivity: mouse.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-RIOK3 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human RIOK3, aa1-519 (NP_003822.2).
• Immunogen Sequence: MDLVGVASPEPGTAAAWGPSKCPWAIPQNTISCSLADVMSEQLAKELQLEEEAAVFPEVAVAEGPFITGENIDTSSDLMLAQMLQMEYDREYDAQLRREEKKFNGDSKVSISFENYRKVHPYEDSDSSEDEVDWQDTRDDPYRPAKPVPTPKKGFIGKGKDITTKHDEVVCGRKNTARMENFAPEFQVGDGIGMDLKLSNHVFNALKQHAYSEERRSARLHEKKEHSTAEKAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHAYGGSMEDEKEDSKVIPTECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMWAEKEMHNLARMQRAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVKLNSEEMKEAYYQTLHLMRQLYHECTLVHADLSEYNMLWHAGKVWLIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVKEALSERELFNAVSGLNITADNEADFLAEIEALEKMNEDHVQKNGRKAASFLKDDGDPPLLYDE
• Conjugate: FITC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(RIOK3 rabbit polyclonal antibody. Western Blot analysis of RIOK3 expression in mouse kidney.)

Western Blot (WB)

(Western Blot analysis of RIOK3 expression in transfected 293T cell line by RIOK3 polyclonal antibody. Lane 1: RIOK3 transfected lysate (59.1kD). Lane 2: Non-transfected lysate.)

Product Categories/Family for anti-RIOK3 antibody

Antibodies; Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 22325377
• NCBI GeneID: 8780
• NCBI Accession #: NP_003822.2
• NCBI GenBank Nucleotide #: NM_003831.2
• UniProt Accession #: O14730; Q8IXN9
• Molecular Weight: 58,671 Da
• NCBI Official Full Name: serine/threonine-protein kinase RIO3
• NCBI Official Synonym Full Names: RIO kinase 3
• NCBI Official Symbol: RIOK3
• NCBI Official Synonym Symbols: SUDD
• NCBI Protein Information: serine/threonine-protein kinase RIO3; sudD homolog; sudD suppressor of bimD6 homolog; homolog of the Aspergillus nidulans sudD gene product; sudD suppressor of Aspergillus nidulans bimD6 homolog; sudD (suppressor of bimD6, Aspergillus nidulans) homolog
• UniProt Protein Name: Serine/threonine-protein kinase RIO3
• UniProt Gene Name: RIOK3
• UniProt Synonym Gene Names: SUDD

NCBI Description

This gene was identified by the similarity of its product to the Aspergillus nidulans SUDD protein, an extragenic suppressor of the heat-sensitive bimD6 mutation that fails to attach properly to the spindle microtubules at a restrictive temperature. The specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843).