Rabbit anti-Human RGS8 Polyclonal Antibody | anti-RGS8 antibody

RGS8, NT (RGS8, Regulator of G-protein signaling 8) (MaxLight 650)

Cat. Num. AAA6341815

• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: RGS8; Polyclonal Antibody; NT (RGS8; Regulator of G-protein signaling 8) (MaxLight 650); Regulator of G-protein signaling 8; anti-RGS8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
• Sequence Length: 198

• Applicable Applications for anti-RGS8 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: RGS8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-43 amino acids from the N-terminal region of human RGS8.
• Conjugate: MaxLight650
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-RGS8 antibody

RGS8 is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation.

Product Categories/Family for anti-RGS8 antibody

Antibodies; G Proteins

References

Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Fujii, S., et al. Biochem. Biophys. Res. Commun. 377(1):200-204(2008). Campbell, D.B., et al. Schizophr. Res. 101 (1-3), 67-75 (2008): Lamesch, P., et al. Genomics 89(3):307-315(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 16117777
• NCBI GeneID: 85397
• NCBI Accession #: NP_203131.1; NP_001095920.1
• NCBI GenBank Nucleotide #: NP_203131.1
• UniProt Accession #: P57771
• NCBI Official Full Name: regulator of G-protein signaling 8 isoform 1
• NCBI Official Synonym Full Names: regulator of G protein signaling 8
• NCBI Official Symbol: RGS8
• NCBI Protein Information: regulator of G-protein signaling 8
• UniProt Protein Name: Regulator of G-protein signaling 8
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS8
• UniProt Synonym Gene Names: RGS8
• UniProt Entry Name: RGS8_HUMAN

NCBI Description

This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]

Uniprot Description

RGS8: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: cytoplasm; plasma membrane

Molecular Function: GTPase activator activity

Biological Process: positive regulation of GTPase activity