Rabbit RGS5 Polyclonal Antibody | anti-RGS5 antibody

RGS5 Polyclonal Antibody

Cat. Num. AAA2524332

• Gene Names: RGS5; MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: RGS5; Polyclonal Antibody; RGS5 Polyclonal Antibody; MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129; anti-RGS5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2.2mg/mL (varies by lot)
• Sequence Length: 185

• Applicable Applications for anti-RGS5 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Recombinant protein of human RGS5
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using RGS5 Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human breast cancer tissue using RGS5 Polyclonal Antibody at dilution 1:40)

Related Product Information for anti-RGS5 antibody

This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified.

NCBI and Uniprot Product Information

• NCBI GI #: 363001551
• NCBI GeneID: 8490
• NCBI Accession #: NP_001241678.1
• NCBI GenBank Nucleotide #: NM_001254749.1
• Molecular Weight: 21,402 Da
• NCBI Official Full Name: regulator of G-protein signaling 5 isoform 3
• NCBI Official Synonym Full Names: regulator of G-protein signaling 5
• NCBI Official Symbol: RGS5
• NCBI Official Synonym Symbols: MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129
• NCBI Protein Information: regulator of G-protein signaling 5
• UniProt Protein Name: Regulator of G-protein signaling 5
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS5
• UniProt Synonym Gene Names: RGS5
• UniProt Entry Name: RGS5_HUMAN

NCBI Description

This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]

Uniprot Description

RGS5: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, RGS

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: cytoplasm; plasma membrane

Molecular Function: GTPase activator activity

Biological Process: signal transduction; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity

Disease: Hypertension, Essential