Rabbit anti-Human RGS2 Polyclonal Antibody | anti-RGS2 antibody

RGS2 Rabbit Polyclonal

Cat. Num. AAA7603502

• Gene Names: RGS2; G0S8
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: RGS2; Polyclonal Antibody; RGS2 Rabbit Polyclonal; anti-RGS2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 211

• Applicable Applications for anti-RGS2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Regulator of G-protein signaling 2, 24kDa
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human pancreas cancer using MBS7603502 (RGS2 antibody) at dilution of 1:50)

Western Blot (WB)

(fetal human brain tissue were subjected to SDS PAGE followed by western blot with MBS7603502 (RGS2 Antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 48146937
• NCBI GeneID: 5997
• UniProt Accession #: P41220; Q6I9U5
• Molecular Weight: 20,780 Da
• NCBI Official Full Name: RGS2
• NCBI Official Synonym Full Names: regulator of G-protein signaling 2
• NCBI Official Symbol: RGS2
• NCBI Official Synonym Symbols: G0S8
• NCBI Protein Information: regulator of G-protein signaling 2
• UniProt Protein Name: Regulator of G-protein signaling 2
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS2
• UniProt Synonym Gene Names: G0S8; RGS2
• UniProt Entry Name: RGS2_HUMAN

NCBI Description

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]

Uniprot Description

RGS2: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. 4 isoforms of the human protein are produced by alternative initiation.

Protein type: GAPs, misc.; GAPs; Nucleolus

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: cytoplasm; cytosol; internal side of plasma membrane; mitochondrion; neuron projection; nucleolus; nucleus; plasma membrane

Molecular Function: beta-tubulin binding; calmodulin binding; G-protein alpha-subunit binding; GTPase activator activity; protein binding

Biological Process: brown fat cell differentiation; cell cycle; negative regulation of G-protein coupled receptor protein signaling pathway; negative regulation of MAP kinase activity; positive regulation of GTPase activity; positive regulation of microtubule polymerization; regulation of G-protein coupled receptor protein signaling pathway; regulation of translation; relaxation of vascular smooth muscle; spermatogenesis