Western Blot (WB)
(AKAP4 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the AKAP4 antibody detected the AKAP4 protein (arrow).)
Rabbit anti-Human AKAP4 Polyclonal Antibody | anti-AKAP4 antibody
AKAP4 Antibody (N-term)
Western Blot (WB)
(AKAP4 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the AKAP4 antibody detected the AKAP4 protein (arrow).)
Western Blot (WB)
(AKAP4 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the AKAP4 antibody detected the AKAP4 protein (arrow).)
Immunohistochemistry (IHC)
(AKAP4 Antibody (N-term) (MBS9208774)immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of AKAP4 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(AKAP4 Antibody (N-term) (MBS9208774)immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of AKAP4 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
structurally diverse proteins, which have the common function of
binding to the regulatory subunit of protein kinase A (PKA) and
confining the holoenzyme to discrete locations within the cell.
This gene encodes a member of the AKAP family. The encoded protein
is localized to the sperm flagellum and may be involved in the
regulation of sperm motility. Alternative splicing of this gene
results in two transcript variants encoding different isoforms.
Lefievre, L., et al. Proteomics 7(17):3066-3084(2007)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
Brown, P.R., et al. Biol. Reprod. 68(6):2241-2248(2003)
Ficarro, S., et al. J. Biol. Chem. 278(13):11579-11589(2003)
NCBI and Uniprot Product Information
NCBI Description
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
AKAP4: Major structural component of sperm fibrous sheath. Plays a role in sperm motility. Belongs to the AKAP110 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cancer Testis Antigen (CTA); Adaptor/scaffold
Chromosomal Location of Human Ortholog: Xp11.2
Cellular Component: cytoskeleton; perinuclear region of cytoplasm; cytoplasm; Z disc; nucleus; cAMP-dependent protein kinase complex
Molecular Function: protein kinase A binding
Biological Process: sperm motility; protein localization; cell projection organization and biogenesis; single fertilization; transmembrane receptor protein serine/threonine kinase signaling pathway; cell motility; signal transduction
Research Articles on AKAP4
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Product Notes
The AKAP4 akap4 (Catalog #AAA9208774) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 10-36. The AKAP4 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's AKAP4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the AKAP4 akap4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AKAP4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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