Rabbit anti-Human Resistin-like Molecule, alpha Polyclonal Antibody | anti-RETNLB antibody

Resistin-like Molecule, alpha (RELMa)

Cat. Num. AAA618476

• Gene Names: RETNLB; XCP2; FIZZ1; FIZZ2; HXCP2; RELMb; RELMbeta; RELM-beta
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Resistin-like Molecule; alpha; Polyclonal Antibody; alpha (RELMa); Anti -Resistin-like Molecule; anti-RETNLB antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes Human RELMa. No significant sequence was found with resistin or RELM-beta.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in 100mM Tris, pH 7.5, 0.2% BSA, 0.05% sodium azide, 40% glycerol.

• Applicable Applications for anti-RETNLB antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Western Blot: 1-5ug/ml using ECL; ELISA: 1:10,000-1:100,000
• Immunogen: A synthetic 13-aa peptide sequence near the N-terminus of Human RELM-alpha (1) coupled with KLH ~9kD.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-RETNLB antibody

Resistance to insulin characterizes type 2 diabetes, the most common form of diabetes. There is a strong link between type 2 diabetes and obesity, as most patients tend to be obese. Thiozolidinediones (TZDs), a new class of anti-diabetic drugs, enhances target-tissue sensitivity to insulin. A screen of genes down regulated by TZD in adipocyte led to the discovery of a new protein hormone called resistin (for resistance to insulin). Resistin, specifically produced and secreted by adipocyte, is present at elevated levels in the blood of obese animals, and is down regulated by fasting and anti-diabetic drugs. Antibody to resistin stimulated glucose uptake and improved insulin sensitivity in obese mice. Some other protein related to resistin has been called resistin-related molecules (RELM-alpha and beta). Resistin family of proteins was also identified as proteins (FIZZ1-3, for Found in Inflammatory zone) involved in allergy and inflammation.

Product Categories/Family for anti-RETNLB antibody

Antibodies; Abs to Resistin

NCBI and Uniprot Product Information

• NCBI GI #: 14211897
• NCBI GeneID: 84666
• NCBI Accession #: NP_115968.1
• NCBI GenBank Nucleotide #: NM_032579.2
• UniProt Accession #: Q9BQ08; Q14D27
• Molecular Weight: 11,730 Da
• NCBI Official Full Name: resistin-like beta
• NCBI Official Synonym Full Names: resistin like beta
• NCBI Official Symbol: RETNLB
• NCBI Official Synonym Symbols: XCP2; FIZZ1; FIZZ2; HXCP2; RELMb; RELMbeta; RELM-beta
• NCBI Protein Information: resistin-like beta; found in inflammatory zone 1; colon carcinoma-related gene protein; cysteine-rich secreted protein FIZZ2; cysteine-rich secreted A12-alpha-like protein 1; cysteine-rich secreted protein A12-alpha-like 1; colon and small intestine-specific cysteine-rich protein; C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 2
• UniProt Protein Name: Resistin-like beta
• Protein Family: Resistin
• UniProt Gene Name: RETNLB
• UniProt Synonym Gene Names: CCRG; FIZZ2; HXCP2; RETNL2
• UniProt Entry Name: RETNB_HUMAN

Uniprot Description

resistin-like beta: Probable hormone. Belongs to the resistin/FIZZ family.

Chromosomal Location of Human Ortholog: 3q13.1

Cellular Component: extracellular region

Molecular Function: hormone activity

Biological Process: cell proliferation