Rabbit anti-Human, Mouse Rel B Polyclonal Antibody | anti-RelB antibody

Rel B Polyclonal Antibody

Cat. Num. AAA3008459

• Gene Names: RELB; IREL; I-REL; IMD53; REL-B
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Rel B; Polyclonal Antibody; Rel B Polyclonal Antibody; IREL; I-REL; REL-B; anti-RelB antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Rel B polyclonal antibody detects endogenous levels of Rel B protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 579

• Applicable Applications for anti-RelB antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant protein of human RELB.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cells, using RELB antibody.)

Related Product Information for anti-RelB antibody

The NFkappaB transcription factor was originally identified as a protein complex consisting of a DNA-binding subunit and an associated protein. The DNAbinding subunit is functionally related to c-Rel p75 and Rel B p68. The p50 subunit was initially believed to be a functionally unique protein derived from the amino-terminus of a precursor designated p105. A second protein designated p52 (previously referred to as p49) has been identified that can act as an alternative NFkappaB subunit. Rel B does not bind with high affinity to NFkappaB sites, but heterodimers between Rel B and p50 bind with an affinity comparable to that of p50 NFkappaB homodimers. However, Rel B/p50 heterodimers, in contrast to NFkappaB heterodimers, transactivates transcription of promotors containing kappaB binding sites.

NCBI and Uniprot Product Information

• NCBI GI #: 35493878
• NCBI GeneID: 5971
• NCBI Accession #: NP_006500.2
• NCBI GenBank Nucleotide #: NP_006500.2
• UniProt Accession #: Q01201
• Molecular Weight: ~ 56kDa
• NCBI Official Full Name: transcription factor RelB
• NCBI Official Synonym Full Names: RELB proto-oncogene, NF-kB subunit
• NCBI Official Symbol: RELB
• NCBI Official Synonym Symbols: IREL; I-REL; IMD53; REL-B
• NCBI Protein Information: transcription factor RelB
• UniProt Protein Name: Transcription factor RelB
• Protein Family: Antitoxin
• UniProt Gene Name: RELB
• UniProt Entry Name: RELB_HUMAN

Uniprot Description

RELB: a transcription factor of the nuclear factor-kappaB (NFkB) transcription complex. Stimulates promoter activity in the presence NFkB1/NFkB-p50. Plays role in regulation of apoptosis in hepatocellular carcinoma through activation of downstream target genes. Does not associate with DNA or RelA/NFkB-p65.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: nucleoplasm; cytoplasm; microtubule organizing center; cytosol

Molecular Function: protein binding; chromatin binding; transcription corepressor activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; antigen processing and presentation; I-kappaB kinase/NF-kappaB cascade; response to cytokine stimulus; T-helper 1 cell differentiation; innate immune response; myeloid dendritic cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; inflammatory response