Rabbit anti-Human Regenerating Protein 1 alpha Polyclonal Antibody | anti-REG3A antibody

Regenerating Protein 1 alpha (REG-1 alpha)

Cat. Num. AAA620035

• Gene Names: REG3A; HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; HIP/PAP; REG-III
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunoprecipitation, Immunocytochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Regenerating Protein 1 alpha; Polyclonal Antibody; Regenerating Protein 1 alpha (REG-1 alpha); Anti -Regenerating Protein 1 alpha (REG-1 alpha); anti-REG3A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Regenerating Protein 1 alpha.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a lyophilized powder from PBS, pH 7.2. No preservative added. Reconstitute with 100ul sterile ddH2O.

• Applicable Applications for anti-REG3A antibody: ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)
• Application Notes: Suitable for use in ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry.
• Immunogen: Recombinant corresponding to 156aa of human Regenerating Protein 1 alpha expressed in E. coli.
• Preparation and Storage: -20 degree C

Related Product Information for anti-REG3A antibody

Reg protein was shown to be stimulated during the regeneration of pancreatic islets. Since then, many Reg-related proteins have been identified in humans and other animals. In human, the four REG family genes, i.e., REG 1 alpha, REG 1 beta, REG-related sequence (RS) and HIP/PAP, have so far been isolated. These Reg-related proteins are classified into four subfamilies according to their aa sequences, but they share a similar structure and physiological function. Reg is a growth factor for pancreatic beta cells and suggests that the administration of Reg could be used as another therapeutic approach for diabetes mellitus. Human REG cDNA encodes a 166aa protein with a 22aa signal peptide. The aa sequence of human REG has 68% homology to that of rat Reg. Reg 1 was found to be expressed mainly in pancreatic beta and acinoductular cells as well as gastric fundic enterochromaffin-like (ECL) cells. Reg I production in ECL cells is stimulated by gastrin, as well as by the proinflammatory cytokine, cytokine-induced neutrophil chemoattractant (CINC)-2Beta. In patients with chronic hypergastrinemia, Reg production is stimulated with the increased proliferation of gastric mucosal cells. Patients with Helicobacter pylori infection also showed increased Reg production in the gastric mucosa, partly via increased plasma gastrin concentration and partly via increased proinflammatory cytokine production. The serum concentration of the reg-protein was significantly higher in patients with various pancreatic diseases than in normal controls, and was also significantly higher in patients with acute pancreatitis or chronic relapsing pancreatitis than in patients with chronic pancreatitis. Furthermore, the serum PSP/reg-protein concentration was also significantly increased in liver cirrhosis, choledocholit-hiasis and various cancers of the digestive system.

Product Categories/Family for anti-REG3A antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 4505605
• NCBI GeneID: 5068
• NCBI Accession #: NP_002571.1
• NCBI GenBank Nucleotide #: NM_002580.2
• UniProt Accession #: Q06141
• Molecular Weight: 19,395 Da
• NCBI Official Full Name: regenerating islet-derived protein 3-alpha
• NCBI Official Synonym Full Names: regenerating islet-derived 3 alpha
• NCBI Official Symbol: REG3A
• NCBI Official Synonym Symbols: HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; HIP/PAP; REG-III
• NCBI Protein Information: regenerating islet-derived protein 3-alpha; REG-3-alpha; reg III-alpha; PAP homologous protein; human proislet peptide; pancreatitis-associated protein 1; proliferation-inducing protein 34; proliferation-inducing protein 42; hepatocarcinoma-intestine-pancreas; pancreatic beta cell growth factor; hepatointestinal pancreatic protein; regenerating islet-derived protein III-alpha
• UniProt Protein Name: Regenerating islet-derived protein 3-alpha
• Protein Family: Regenerating islet-derived protein
• UniProt Gene Name: REG3A
• UniProt Synonym Gene Names: HIP; PAP; PAP1; REG-3-alpha; HIP/PAP
• UniProt Entry Name: REG3A_HUMAN

NCBI Description

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Dec 2010]

Uniprot Description

REG3A: Might be a stress protein involved in the control of bacterial proliferation.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: extracellular space; cytoplasm

Molecular Function: carbohydrate binding

Biological Process: heterophilic cell adhesion; cell proliferation; multicellular organismal development; negative regulation of keratinocyte differentiation; acute-phase response