Rabbit anti-Human RC3H2 Polyclonal Antibody | anti-RC3H2 antibody

RC3H2 Antibody

Cat. Num. AAA969985

• Gene Names: RC3H2; MNAB; RNF164
• Reactivity: Human
• Applications: ELISA
• Purity: >95%,Protein G purified
• Synonyms: RC3H2; Polyclonal Antibody; RC3H2 Antibody; Roquin-2; Membrane-associated nucleic acid-binding protein; RING finger and CCCH-type zinc finger domain-containing protein 2; RING finger protein 164; MNAB; RNF164; anti-RC3H2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%,Protein G purified
• Form/Format: Liquid
• Sequence Length: 1191

• Applicable Applications for anti-RC3H2 antibody: ELISA (EIA)
• Immunogen: Recombinant human Roquin-2 protein
• Conjugation: Non-conjugated
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-165026 / sc-165028
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Related Product Information for anti-RC3H2 antibody

Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation. May act as a ubiquitin E3 ligase. Involved in the ubiquitination of MAP3K5 (PubMed:24448648).

NCBI and Uniprot Product Information

• NCBI GI #: 156105697
• NCBI GeneID: 54542
• NCBI Accession #: NP_001094058.1
• NCBI GenBank Nucleotide #: NM_001100588.1
• UniProt Accession #: Q9HBD1; Q4VXB1; Q5JPD7; Q86ST6; Q8N3D6; Q96F27; Q9H5J2; Q9HBD2; Q9NWN9; Q9NXE1
• Molecular Weight: 96,362 Da
• NCBI Official Full Name: roquin-2 isoform 1
• NCBI Official Synonym Full Names: ring finger and CCCH-type domains 2
• NCBI Official Symbol: RC3H2
• NCBI Official Synonym Symbols: MNAB; RNF164
• NCBI Protein Information: roquin-2
• UniProt Protein Name: Roquin-2
• Protein Family: Roquin
• UniProt Gene Name: RC3H2
• UniProt Synonym Gene Names: MNAB; RNF164
• UniProt Entry Name: RC3H2_HUMAN

Uniprot Description

MNAB: 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; DNA-binding

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: cell surface; cytoplasm; membrane; nucleoplasm

Molecular Function: DNA binding; ligase activity; mRNA binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: alveolus development; B cell homeostasis; limb development; lymph node development; multicellular organism growth; post-embryonic development; protein polyubiquitination; spleen development; T cell homeostasis; T cell proliferation