Rabbit anti-Human RBM9 Polyclonal Antibody | anti-RBFOX2 antibody

RBM9 (RNA Binding Motif Protein 9, RNA Binding Protein 9, Hexaribonucleotide Binding Protein 2, HRNBP2, Repressor of Tamoxifen Transcriptional Activity, RTA)

Cat. Num. AAA6002292

• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: RBM9; Polyclonal Antibody; RBM9 (RNA Binding Motif Protein 9; RNA Binding Protein 9; Hexaribonucleotide Binding Protein 2; HRNBP2; Repressor of Tamoxifen Transcriptional Activity; RTA); Anti -RBM9 (RNA Binding Motif Protein 9; anti-RBFOX2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human RBM9.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MEKKKMVTQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTGEHNLTLYGSTQAHGEQSSNSPSTQNGSLTTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY

• Applicable Applications for anti-RBFOX2 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human RBM9, aa1-380 (NP_001026865.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(RBM9 rabbit polyclonal antibody. Western Blot analysis of RBM9 expression in human kidney.)

Western Blot (WB)

(Western Blot analysis of RBM9 expression in transfected 293T cell line by RBM9 polyclonal antibody. Lane 1: RBM9 transfected lysate (40.4kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-RBFOX2 antibody

This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Product Categories/Family for anti-RBFOX2 antibody

Antibodies; Abs to RNA Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 47678649
• UniProt Accession #: O43251; Q0PRL5; Q0VH35; Q5TF71; Q6IC09; Q8TD00; Q8WYB1; Q96DZ6; A4F5G8; A8K5Z5; B0QYY8; B0QYY9
• Molecular Weight: 41,374 Da
• NCBI Official Full Name: RBM9
• UniProt Protein Name: RNA binding protein fox-1 homolog 2
• Protein Family: RNA binding protein
• UniProt Gene Name: RBFOX2
• UniProt Synonym Gene Names: FOX2; HRNBP2; RBM9; RTA
• UniProt Entry Name: RFOX2_HUMAN

Uniprot Description

RBM9: RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. RNA-binding protein that seems to act as a coregulatory factor of ER-alpha. 10 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; RNA-binding; Nuclear receptor co-regulator; RNA splicing

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: mRNA binding; protein binding; RNA binding; nucleotide binding; transcription corepressor activity; transcription factor binding

Biological Process: estrogen receptor signaling pathway; RNA metabolic process; dendrite morphogenesis; radial glia guided migration of Purkinje cell; RNA splicing; mRNA processing; neuromuscular process controlling balance; negative regulation of transcription, DNA-dependent; regulation of alternative nuclear mRNA splicing, via spliceosome; regulation of cell proliferation