Rabbit anti-Human, Mouse RBBP6 Polyclonal Antibody | anti-RBBP6 antibody

Anti-RBBP6 Antibody

Cat. Num. AAA416238

• Gene Names: Rbbp6; PACT; P2P-R; C77662; AI316869; BB233631; 4933422O15Rik; C030034J04Rik
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Affinity purified
• Synonyms: RBBP6; Polyclonal Antibody; Anti-RBBP6 Antibody; anti-RBBP6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 1790

• Applicable Applications for anti-RBBP6 antibody: Immunohistochemistry (IHC)
• Application Notes: Optimal dilutions to be determined by researchers
• Storage Buffer: PBS, pH 7.4 with 0.02% Sodium Azide
• Immunogen: Recombinant protein
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Immunohistochemistry (IHC)

Related Product Information for anti-RBBP6 antibody

The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NCBI and Uniprot Product Information

• NCBI GI #: 163937858
• NCBI GeneID: 19647
• NCBI Accession #: NP_035377
• NCBI GenBank Nucleotide #: NM_011247.2
• Molecular Weight: 17,888 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase RBBP6 isoform 1
• NCBI Official Synonym Full Names: retinoblastoma binding protein 6
• NCBI Official Symbol: Rbbp6
• NCBI Official Synonym Symbols: PACT; P2P-R; C77662; AI316869; BB233631; 4933422O15Rik; C030034J04Rik
• NCBI Protein Information: E3 ubiquitin-protein ligase RBBP6; p53-associated cellular protein of testis; proliferation potential-related protein; protein P2P-R; retinoblastoma-binding protein 6
• UniProt Protein Name: E3 ubiquitin-protein ligase RBBP6
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: Rbbp6
• UniProt Entry Name: RBBP6_MOUSE

Uniprot Description

RBBP6: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus; Ubiquitin conjugating system; Ligase; Cell cycle regulation; EC 6.3.2.-; Ubiquitin ligase; EC 6.3.2.19

Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; chromosome; nucleus

Molecular Function: nucleic acid binding; zinc ion binding; coenzyme F420-2 alpha-glutamyl ligase activity; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; metal ion binding; ribosomal S6-glutamic acid ligase activity; ubiquitin-protein ligase activity; coenzyme F420-0 gamma-glutamyl ligase activity; ligase activity

Biological Process: in utero embryonic development; multicellular organism growth; protein ubiquitination during ubiquitin-dependent protein catabolic process; embryonic organ development