Rabbit RASA4 Polyclonal Antibody | anti-RASA4 antibody
RASA4
Gene Names
RASA4; GAPL; CAPRI
Reactivity
HumanPredicted: Rat, Mouse
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Purified By Antigen Affinity Column
Synonyms
RASA4; Polyclonal Antibody; anti-RASA4 antibody
Host
Rabbit
Reactivity
Human
Predicted: Rat, Mouse
Predicted: Rat, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified By Antigen Affinity Column
Form/Format
Already dissolved in sterile H2O with 1% BSA and 0.02% NaN3 and 50% Glycerol.
Sequence Length
2522
Applicable Applications for anti-RASA4 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
ELISA: 1:20,000-80,000
WB: 1:200-1,000
IHC: 1:100-500
WB: 1:200-1,000
IHC: 1:100-500
Immunogen
Recombinant fragment corresponding to 69-301aa of human RASA4.
Cellular Localization
Cytoplasm, Cell Membrane
Related Product Information for anti-RASA4 antibody
Homo sapiens RAS p21 protein activator 4 (RASA4), transcript variant 2, mRNA.
References
Dai Y, Walker SA, de Vet E. et al. Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities. J Biol Chem. 286(22):19905-16 (2011)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
87KD
NCBI Official Full Name
Homo sapiens RAS p21 protein activator 4, mRNA
NCBI Official Synonym Full Names
RAS p21 protein activator 4
NCBI Official Symbol
RASA4
NCBI Official Synonym Symbols
GAPL; CAPRI
NCBI Protein Information
ras GTPase-activating protein 4
Protein Family
NCBI Description
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Research Articles on RASA4
Similar Products
Product Notes
The RASA4 (Catalog #AAA8560895) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RASA4 reacts with Human Predicted: Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's RASA4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). ELISA: 1:20,000-80,000 WB: 1:200-1,000 IHC: 1:100-500. Researchers should empirically determine the suitability of the RASA4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RASA4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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