Rabbit RAP1GDS1 Polyclonal Antibody | anti-RAP1GDS1 antibody

RAP1GDS1 Rabbit Polyclonal

Cat. Num. AAA7603345

• Gene Names: RAP1GDS1; GDS1; SmgGDS
• Reactivity: Human, Mouse; other species are not tested.
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: RAP1GDS1; Polyclonal Antibody; RAP1GDS1 Rabbit Polyclonal; Exchange factor smgGDS; GDS1; SMG GDS protein; SmgGDS; anti-RAP1GDS1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse; other species are not tested.
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Please decide the specificity by homology
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 516

• Applicable Applications for anti-RAP1GDS1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Application Notes: Western Blot(WB) 1:500-1:1000; Immunoprecipitation (IP) 1:500-1:1000; Immunohistochemistry (IHC) 1:50-1:500
• Immunogen: RAP1, GTP-GDP dissociation stimulator 1
• Calculated MW: 66 kDa
• Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3
• Preparation and Storage: Store at -20°C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human gliomas tissue slide using MBS7603345 (RAP1GDS1 Antibody) at dilution of 1:100)

Western Blot (WB)

(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS7603345 (RAP1GDS1 Antibody) at dilution of 1:600)

Related Product Information for anti-RAP1GDS1 antibody

Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins(G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein.

NCBI and Uniprot Product Information

• NCBI GI #: 155030202
• NCBI GeneID: 5910
• NCBI Accession #: NP_001093900.1
• NCBI GenBank Nucleotide #: NM_001100430.1
• NCBI Official Full Name: rap1 GTPase-GDP dissociation stimulator 1 isoform 6
• NCBI Official Synonym Full Names: Rap1 GTPase-GDP dissociation stimulator 1
• NCBI Official Symbol: RAP1GDS1
• NCBI Official Synonym Symbols: GDS1; SmgGDS
• NCBI Protein Information: rap1 GTPase-GDP dissociation stimulator 1
• UniProt Protein Name: Rap1 GTPase-GDP dissociation stimulator 1
• Protein Family: Rap1 GTPase-GDP dissociation stimulator
• UniProt Gene Name: RAP1GDS1
• UniProt Entry Name: GDS1_HUMAN

NCBI Description

The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010]

Uniprot Description

RAP1GDS1: Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs, misc.; GEFs

Chromosomal Location of Human Ortholog: 4q23-q25

Cellular Component: cytosol; endoplasmic reticulum; mitochondrion

Molecular Function: GTPase activator activity; protein binding

Biological Process: elevation of mitochondrial calcium ion concentration; positive regulation of GTPase activity; reduction of endoplasmic reticulum calcium ion concentration; small GTPase mediated signal transduction