Goat anti-Human RAE1 Polyclonal Antibody | anti-RAE1 antibody

RAE1, CT (RAE1 RNA Export 1 Homolog (S. pombe), Rae1 Protein Homolog, MIG14, mRNA Export Factor, mRNA-associated Protein mrnp 41, Mnrp41, MRNP41)

Cat. Num. AAA6010313

• Gene Names: RAE1; MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: RAE1; Polyclonal Antibody; CT (RAE1 RNA Export 1 Homolog (S. pombe); Rae1 Protein Homolog; MIG14; mRNA Export Factor; mRNA-associated Protein mrnp 41; Mnrp41; MRNP41); Anti -RAE1; anti-RAE1 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human RAE1. Species sequence homology: bovine, canine, mouse, porcine and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-RAE1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot and Immunohistochemistry.; Dilution: ELISA: 1:64,000; Western Blot: 0.03-0.1ug/ml; Immunohistochemistry (Formalin fixed paraffin embedded): 3.75ug/ml
• Immunogen: Synthetic peptide C-NAAEELKPRNKK from the C-terminus of human RAE1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Antibody staining (0.03ug/ml) of HepG2 lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)

Immunohistochemistry (IHC)

(Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-RAE1 antibody

Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Product Categories/Family for anti-RAE1 antibody

Antibodies; Abs to RNA Processing

NCBI and Uniprot Product Information

• NCBI GI #: 119595931
• NCBI GeneID: 8480
• UniProt Accession #: P78406; O15306; Q3SYL7; Q5TCH8; Q6V708; Q9H100; Q9NQM6; A8K882
• Molecular Weight: 40,968 Da
• NCBI Official Full Name: RAE1 RNA export 1 homolog (S. pombe), isoform CRA_a
• NCBI Official Synonym Full Names: ribonucleic acid export 1
• NCBI Official Symbol: RAE1
• NCBI Official Synonym Symbols: MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1
• NCBI Protein Information: mRNA export factor; mRNA export protein; rae1 protein homolog; RAE1 RNA export 1 homolog; migration-inducing gene 14; mRNA-binding protein, 41-kD; mRNA-associated protein MRNP 41; homolog of yeast Rae1 (Bharathi) mRNA-associated protein of 41 kDa (Kraemer)
• UniProt Protein Name: mRNA export factor
• Protein Family: Protein
• UniProt Gene Name: RAE1
• UniProt Synonym Gene Names: MRNP41
• UniProt Entry Name: RAE1L_HUMAN

NCBI Description

Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

RAE1: Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Belongs to the WD repeat rae1 family.

Protein type: RNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q13.31

Cellular Component: nuclear outer membrane; cytoskeleton; cytoplasm; nucleolus; nuclear envelope; nuclear pore; nucleus

Molecular Function: RNA binding; microtubule binding

Biological Process: viral reproduction; cytokine and chemokine mediated signaling pathway; mitotic nuclear envelope disassembly; pathogenesis; viral infectious cycle; glucose transport; mRNA export from nucleus; hexose transport; carbohydrate metabolic process; gene expression; viral transcription; mitotic cell cycle; transmembrane transport