Rabbit RAE1 Polyclonal Antibody | anti-RAE1 antibody

RAE1 antibody

Cat. Num. AAA9413347

• Gene Names: RAE1; MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunofluorescence
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: RAE1; Polyclonal Antibody; RAE1 antibody; MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1; anti-RAE1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total RAE1 antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 368

• Applicable Applications for anti-RAE1 antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: Western blotting: 1:500 - 1:2000; Immunofluorescence: 1:50 - 1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human RAE1.
• Target Name: RAE1
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using RAE1 antibody.)

Immunofluorescence (IF)

(Immunofluorescence analysis of MCF7 cell using RAE1 antibody. Blue: DAPI for nuclear staining.)

Related Product Information for anti-RAE1 antibody

Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Product Categories/Family for anti-RAE1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 62739173
• NCBI GeneID: 8480
• NCBI Accession #: NP_001015885.1
• NCBI GenBank Nucleotide #: NM_001015885.1
• UniProt Accession #: P78406; O15306; Q3SYL7; Q5TCH8; Q6V708; Q9H100; Q9NQM6; A8K882
• Molecular Weight: 40,968 Da
• NCBI Official Full Name: mRNA export factor
• NCBI Official Synonym Full Names: ribonucleic acid export 1
• NCBI Official Symbol: RAE1
• NCBI Official Synonym Symbols: MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1
• NCBI Protein Information: mRNA export factor
• UniProt Protein Name: mRNA export factor
• Protein Family: Protein
• UniProt Gene Name: RAE1
• UniProt Synonym Gene Names: MRNP41
• UniProt Entry Name: RAE1L_HUMAN

NCBI Description

Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

RAE1: Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Belongs to the WD repeat rae1 family.

Protein type: RNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q13.31

Cellular Component: nuclear outer membrane; cytoskeleton; cytoplasm; nucleolus; nuclear envelope; nuclear pore; nucleus

Molecular Function: RNA binding; microtubule binding

Biological Process: mRNA export from nucleus; viral reproduction; hexose transport; cytokine and chemokine mediated signaling pathway; carbohydrate metabolic process; mitotic nuclear envelope disassembly; gene expression; pathogenesis; viral transcription; glucose transport; viral infectious cycle; mitotic cell cycle; transmembrane transport