Western Blot (WB)
(Western blot analysis of human HeLa (heat shocked) cell lysate, probed with Rab5 pAb.)
Rabbit RAB5 Polyclonal Antibody | anti-Ras-related protein Rab-5 antibody
RAB5 polyclonal antibody
Suggested dilutions/conditions may not be available for all applications.
Detects a band of ~26kDa by Western blot.
Avoid freeze/thaw cycles.
Western Blot (WB)
(Western blot analysis of human HeLa (heat shocked) cell lysate, probed with Rab5 pAb.)
Western Blot (WB)
(Western blot analysis of human HeLa (heat shocked) cell lysate, probed with Rab5 pAb.)
NCBI and Uniprot Product Information
Uniprot Description
RAB5A: Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, RABEP1, SUN2, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3. Interacts with PIK3CB. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Belongs to the small GTPase superfamily. Rab family.
Protein type: G protein, monomeric; Motility/polarity/chemotaxis; G protein; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 3p24-p22
Cellular Component: actin cytoskeleton; axon; cell soma; cytoplasm; cytosol; dendrite; early endosome; endocytic vesicle; endosome; endosome membrane; lipid raft; melanosome; nerve terminal; phagocytic vesicle; plasma membrane; ruffle; synaptic vesicle; terminal button
Molecular Function: GDP binding; GTP binding; GTPase activity; protein binding
Biological Process: blood coagulation; early endosome to late endosome transport; endocytosis; positive regulation of exocytosis; protein transport; regulation of endocytosis; regulation of endosome size; regulation of filopodium formation; small GTPase mediated signal transduction
Research Articles on Ras-related protein Rab-5
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Product Notes
The Ras-related protein Rab-5 rab5a (Catalog #AAA565208) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RAB5 polyclonal antibody reacts with Human, Mouse, Rat, Bovine, Dog, Guinea pig, Hamster, Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's RAB5 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blot (WB). Western Blot (1:1,000, ECL) Suggested dilutions/conditions may not be available for all applications. Detects a band of ~26kDa by Western blot. Researchers should empirically determine the suitability of the Ras-related protein Rab-5 rab5a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RAB5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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