Rabbit RAB4A Polyclonal Antibody | anti-RAB4A antibody

RAB4A Rabbit Polyclonal

Cat. Num. AAA7603270

• Gene Names: RAB4A; RAB4; HRES1; HRES-1; HRES-1/RAB4
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: RAB4A; Polyclonal Antibody; RAB4A Rabbit Polyclonal; anti-RAB4A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 150

• Applicable Applications for anti-RAB4A antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: RAB4A, member RAS oncogene family
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human heart tissue slide using MBS7603270 (RAB4A Antibody) at dilution of 1:200)

Immunofluorescence (IF)

(Immunofluorescent analysis of (-20 degree C Ethanol) fixed NIH/3T3 cells using MBS7603270 (RAB4A Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L))

Western Blot (WB)

(fetal human brain tissue were subjected to SDS PAGE followed by western blot with MBS7603270 (RAB4A Antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 119590301
• NCBI GeneID: 5867
• Molecular Weight: 24,390 Da
• NCBI Official Full Name: RAB4A, member RAS oncogene family, isoform CRA_f
• NCBI Official Synonym Full Names: RAB4A, member RAS oncogene family
• NCBI Official Symbol: RAB4A
• NCBI Official Synonym Symbols: RAB4; HRES1; HRES-1; HRES-1/RAB4
• NCBI Protein Information: ras-related protein Rab-4A
• UniProt Protein Name: Ras-related protein Rab-4A
• Protein Family: Ras-related protein
• UniProt Gene Name: RAB4A
• UniProt Synonym Gene Names: RAB4
• UniProt Entry Name: RAB4A_HUMAN

NCBI Description

This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

Uniprot Description

Rab4: a member of the RAB family of RAS-related GTP-binding proteins, important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori. Mutations in this protein cause Charcot-Marie-Tooth type 2B neuropathy.

Protein type: G protein; G protein, monomeric, Rab; G protein, monomeric

Chromosomal Location of Human Ortholog: 1q42-q43

Cellular Component: cytosol; endosome; perinuclear region of cytoplasm; plasma membrane; recycling endosome; vesicle

Molecular Function: ATPase activator activity; ATPase binding; GDP binding; GTP binding; GTPase activity; ionotropic glutamate receptor binding; protein binding; protein transporter activity; syntaxin binding

Biological Process: antigen processing and presentation; intracellular protein transport; metabolic process; nucleocytoplasmic transport; positive regulation of ATPase activity; Rab protein signal transduction; regulation of endocytosis