Western Blot (WB)
(Anti- Rab3A Picoband antibody, MBS178079, Western blottingAll lanes: Anti Rab3A (MBS178079) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: Mouse Brain Tissue Lysate at 50ugPredicted bind size: 25KDObserved bind size: 25KD )
Rab3A Polyclonal Antibody | anti-RAB3A antibody
Anti-Rab3A Antibody
Predicted to work with: Human
Predicted to work with: Human
Western Blot (WB)
(Anti- Rab3A Picoband antibody, MBS178079, Western blottingAll lanes: Anti Rab3A (MBS178079) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: Mouse Brain Tissue Lysate at 50ugPredicted bind size: 25KDObserved bind size: 25KD )
Western Blot (WB)
(Anti- Rab3A Picoband antibody, MBS178079, Western blottingAll lanes: Anti Rab3A (MBS178079) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: Mouse Brain Tissue Lysate at 50ugPredicted bind size: 25KDObserved bind size: 25KD )
Background: Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene. This gene is mapped to 19p13.11. Synapsin I stimulated the RAB3A cycle by increasing GTP binding, GTPase activity, and RAB3A recruitment to the synaptic vesicle membrane. Conversely, RAB3A inhibited synapsin I binding to actin and synapsin I-induced synaptic vesicle clustering. It has been found that RAB3A was necessary for both forms of synaptic plasticity, and it is also involved in calcium exocytosis in neurons. In addition to that, RAB3A has been found to regulate a late step in synaptic vesicle fusion.
NCBI and Uniprot Product Information
Uniprot Description
RAB3A: Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal. Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A. Interacts with the exocyst complex through SEC15. Binds SYTL4, RIMS1 and RIMS2. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3. Specifically expressed in brain. Belongs to the small GTPase superfamily. Rab family.
Protein type: G protein, monomeric; G protein; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: acrosome; axon; cytosol; endosome; plasma membrane; protein complex; synaptic vesicle; terminal button
Molecular Function: ATPase activator activity; ATPase binding; GTP binding; GTPase activity; GTPase binding; myosin V binding; protein binding; protein C-terminus binding
Biological Process: axonogenesis; constitutive secretory pathway; glutamate secretion; intracellular protein transport; lung development; maintenance of presynaptic active zone structure; metabolic process; mitochondrion organization and biogenesis; neuromuscular synaptic transmission; neurotransmitter secretion; nucleocytoplasmic transport; positive regulation of ATPase activity; positive regulation of exocytosis; post-embryonic development; regulation of short-term neuronal synaptic plasticity; regulation of synaptic vesicle fusion to presynaptic membrane; respiratory system process; response to electrical stimulus; sensory perception of touch; small GTPase mediated signal transduction; synaptic vesicle exocytosis; synaptic vesicle maturation
Research Articles on RAB3A
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Product Notes
The RAB3A rab3a (Catalog #AAA178079) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-Rab3A Antibody reacts with Mouse, Rat Predicted to work with: Human and may cross-react with other species as described in the data sheet. AAA Biotech's Rab3A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the RAB3A rab3a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Rab3A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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