Rabbit RAB35 Polyclonal Antibody | anti-RAB35 antibody

RAB35 Antibody

Cat. Num. AAA9407213

• Gene Names: RAB35; RAY; H-ray; RAB1C
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: RAB35; Polyclonal Antibody; RAB35 Antibody; RAY; H-ray; RAB1C; anti-RAB35 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total RAB35 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 152

• Applicable Applications for anti-RAB35 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50-1:150
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human Ras-related protein Rab-35
• Target Name: RAB35
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/100.)

Related Product Information for anti-RAB35 antibody

This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. Rab35 plays an important role in insulin-stimulated GLUT4 translocation in adipocytes.It is the target of TBC1D10A¨CC and that the intracellular accumulation of endosomal vesicles and impairs exosome secretion were occured when inhibition of Rab35 function.The surface of oligodendroglia in a GTP-dependent manner was localized Rab35, it increases the density of vesicles, and may have a function in docking or tethering.

Product Categories/Family for anti-RAB35 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 262527293
• NCBI GeneID: 11021
• NCBI Accession #: NP_001161078.1
• NCBI GenBank Nucleotide #: NM_001167606.1
• UniProt Accession #: Q15286; B2R6E0; B4E390
• Molecular Weight: 17,058 Da
• NCBI Official Full Name: ras-related protein Rab-35 isoform 2
• NCBI Official Synonym Full Names: RAB35, member RAS oncogene family
• NCBI Official Symbol: RAB35
• NCBI Official Synonym Symbols: RAY; H-ray; RAB1C
• NCBI Protein Information: ras-related protein Rab-35
• UniProt Protein Name: Ras-related protein Rab-35
• Protein Family: Ras-related protein
• UniProt Gene Name: RAB35
• UniProt Synonym Gene Names: RAB1C; RAY
• UniProt Entry Name: RAB35_HUMAN

Uniprot Description

RAB35: In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. Interacts with DENND1A and DENND1B in a nucleotide- dependent manner. The low binding to DENND1C is nucleotide- independent. All 3 DENND1 act as GEFs for RAB35 and thus activate the protein. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, monomeric, Rab; G protein; G protein, monomeric

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; intercellular bridge; mitochondrion; cell projection membrane; melanosome; plasma membrane; endosome membrane; coated pit; clathrin-coated endocytic vesicle

Molecular Function: GTPase activity; protein binding; phosphatidylinositol-4,5-bisphosphate binding; GDP binding; GTP binding

Biological Process: intracellular protein transport; antigen processing and presentation; protein localization; ER to Golgi vesicle-mediated transport; metabolic process; cytokinesis; plasma membrane to endosome transport; Rab protein signal transduction; endosome transport; endocytic recycling; neurite development