Rabbit RAB26 Polyclonal Antibody | anti-RAB26 antibody

RAB26 Polyclonal Antibody

Cat. Num. AAA3007528

• Gene Names: RAB26; V46133
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: RAB26; Polyclonal Antibody; RAB26 Polyclonal Antibody; Ras-related protein Rab-26; anti-RAB26 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: RAB26 polyclonal antibody detects endogenous levels of RAB26 protein6.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 256

• Applicable Applications for anti-RAB26 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding Human RAB26.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of RAB26 polyclonal antibody at 1:500 dilutionLane1:A549 whole cell lysate (40ug) Lane2:HepG2 whole cell lysate (40ug) Lane3:L02 whole cell lysate (40ug) Lane4:C6 whole cell lysate (40ug) Lane5:The Brain tissue lysate of Mouse (40ug))

Related Product Information for anti-RAB26 antibody

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland. The Ras-related superfamily of guanine nucleotide binding proteins, which includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies, exhibits 30-60% homology with Ras p21. Accumulating data suggests an important role for Rab proteins, either in endocytosis or in biosynthetic protein transport. The transport of newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves at each stage the movement of carrier vesicles, a process that appears to involve Rab protein function. The possibility that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the SEC4 protein, which is 40% homologous to Rab proteins, is associated with secretory vesicles. At least eight members of the Rab subfamily have been identified, each of which is found at a particular stage of a membrane transport pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 46361978
• NCBI GeneID: 25837
• NCBI Accession #: NP_055168.2
• NCBI GenBank Nucleotide #: NP_055168.2
• UniProt Accession #: Q9ULW5
• Molecular Weight: ~ 28kDa
• NCBI Official Full Name: ras-related protein Rab-26 isoform 1
• NCBI Official Synonym Full Names: RAB26, member RAS oncogene family
• NCBI Official Symbol: RAB26
• NCBI Official Synonym Symbols: V46133
• NCBI Protein Information: ras-related protein Rab-26
• UniProt Protein Name: Ras-related protein Rab-26
• Protein Family: Ras-related protein
• UniProt Gene Name: RAB26
• UniProt Entry Name: RAB26_HUMAN

NCBI Description

Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM, Nov 2010]

Uniprot Description

RAB26: Participates in exocrine secretion: regulates the secretion of acinar granules in the parotid gland. Belongs to the small GTPase superfamily. Rab family.

Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: Golgi membrane; secretory granule membrane; plasma membrane; endosome; intrinsic to plasma membrane

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; GMP binding

Biological Process: regulation of exocytosis; regulated secretory pathway; metabolic process; Golgi to plasma membrane protein transport; protein secretion; exocrine system development; Rab protein signal transduction; vesicle docking during exocytosis