Western Blot (WB)
(Western BlotPositive WB detected in:K562 whole cell lysate,Mouse liver tissue,Mouse lung tissue,Mouse kidney tissue,Mouse brain tissueAll lanes: QDPR antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 26,23 kDaObserved band size: 26 kDa)
Rabbit anti-Human QDPR Polyclonal Antibody | anti-QDPR antibody
QDPR Antibody
Western Blot (WB)
(Western BlotPositive WB detected in:K562 whole cell lysate,Mouse liver tissue,Mouse lung tissue,Mouse kidney tissue,Mouse brain tissueAll lanes: QDPR antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 26,23 kDaObserved band size: 26 kDa)
Western Blot (WB)
(Western BlotPositive WB detected in:K562 whole cell lysate,Mouse liver tissue,Mouse lung tissue,Mouse kidney tissue,Mouse brain tissueAll lanes: QDPR antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 26,23 kDaObserved band size: 26 kDa)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human ovarian cancer using MBS7004468 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human ovarian cancer using MBS7004468 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunofluorescent analysis of A549 cells using MBS7004468 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Immunohistochemistry (IHC)
(Immunofluorescent analysis of A549 cells using MBS7004468 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq, Jul 2008]
Uniprot Description
QDPR: The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases. Defects in QDPR are the cause of BH4-deficient hyperphenylalaninemia type C (HPABH4C); also called dihydropteridine reductase deficiency (DHPR deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to DHPR deficiency or quinoid dihydropteridine reductase deficiency (QDPR deficiency). HPABH4C is a rare autosomal recessive disorder characterized by hyperphenylalaninemia and severe neurologic symptoms (malignant hyperphenylalaninemia) including axial hypotonia and truncal hypertonia, abnormal thermogenesis, and microcephaly. These signs are attributable to depletion of the neurotransmitters dopamine and serotonin, whose syntheses are controlled by tryptophan and tyrosine hydroxylases that use BH-4 as cofactor. These patients do not respond to phenylalanine- restricted diet. HPABH4C is lethal if untreated. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein type: Oxidoreductase; EC 1.5.1.34; Cofactor and Vitamin Metabolism - folate biosynthesis
Chromosomal Location of Human Ortholog: 4p15.31
Cellular Component: cytoplasm; cytosol; mitochondrion; neuron projection
Molecular Function: 6,7-dihydropteridine reductase activity; electron carrier activity; protein homodimerization activity
Biological Process: amino acid metabolic process; dihydrobiopterin metabolic process; L-phenylalanine catabolic process; liver development; response to aluminum ion; response to glucagon stimulus; response to lead ion; tetrahydrobiopterin biosynthetic process
Disease: Hyperphenylalaninemia, Bh4-deficient, C
Research Articles on QDPR
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Product Notes
The QDPR qdpr (Catalog #AAA7004468) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The QDPR Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's QDPR can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the QDPR qdpr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "QDPR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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