Rabbit anti-Human PYCR2 Polyclonal Antibody | anti-PYCR2 antibody

PYCR2 Antibody

Cat. Num. AAA1499163

• Gene Names: PYCR2; HLD10; P5CR2
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >95%, Protein G Purified
• Synonyms: PYCR2; Polyclonal Antibody; PYCR2 Antibody; Pyrroline-5-carboxylate reductase 2 (EC:1.5.1.2); P5C reductase 2; P5CR 2; anti-PYCR2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G Purified
• Sequence Length: 246

• Applicable Applications for anti-PYCR2 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: IHC:1:20-1:200
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: Non-conjugated
• Immunogen: Recombinant human Pyrroline-5-carboxylate reductase 2 protein
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-138500
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human testis tissue using MBS1499163 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human rectum tissue using MBS1499163 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney tissue using MBS1499163 at dilution of 1:100)

Related Product Information for anti-PYCR2 antibody

Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (PubMed:2722838, PubMed:6894153). Involved in cellular response to oxidative stress (PubMed:25865492).

NCBI and Uniprot Product Information

• NCBI GI #: 410991931
• NCBI GeneID: 29920
• NCBI Accession #: NP_001258610.1
• NCBI GenBank Nucleotide #: NM_001271681.1
• UniProt Accession #: Q96C36; Q7Z515; Q9Y5J4; A8K798
• Molecular Weight: 33,637 Da
• NCBI Official Full Name: pyrroline-5-carboxylate reductase 2 isoform 2
• NCBI Official Synonym Full Names: pyrroline-5-carboxylate reductase family member 2
• NCBI Official Symbol: PYCR2
• NCBI Official Synonym Symbols: HLD10; P5CR2
• NCBI Protein Information: pyrroline-5-carboxylate reductase 2
• UniProt Protein Name: Pyrroline-5-carboxylate reductase 2
• Protein Family: Pyrroline-5-carboxylate reductase
• UniProt Gene Name: PYCR2
• UniProt Synonym Gene Names: P5C reductase 2; P5CR 2
• UniProt Entry Name: P5CR2_HUMAN

NCBI Description

This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

Uniprot Description

PYCR2: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH. Belongs to the pyrroline-5-carboxylate reductase family.

Protein type: EC 1.5.1.2; Oxidoreductase; Amino Acid Metabolism - arginine and proline

Chromosomal Location of Human Ortholog: 1q42.12

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: pyrroline-5-carboxylate reductase activity

Biological Process: amino acid biosynthetic process; proline biosynthetic process

Disease: Leukodystrophy, Hypomyelinating, 10