Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human tonsil tissue using PTPRS Polyclonal Antibody at dilution of 1:110(×200))
Rabbit PTPRS Polyclonal Antibody | anti-PTPRS antibody
PTPRS Polyclonal Antibody
ELISA: 1:5000-1:10000
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human tonsil tissue using PTPRS Polyclonal Antibody at dilution of 1:110(×200))
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human tonsil tissue using PTPRS Polyclonal Antibody at dilution of 1:110(×200))
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using PTPRS Polyclonal Antibody at dilution of 1:110(×200))
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using PTPRS Polyclonal Antibody at dilution of 1:110(×200))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120).
Research Articles on PTPRS
Similar Products
Product Notes
The PTPRS ptprs (Catalog #AAA2562931) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTPRS Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PTPRS can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), ELISA (EIA). IHC: 1:100-1:300 ELISA: 1:5000-1:10000. Researchers should empirically determine the suitability of the PTPRS ptprs for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTPRS, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
