Rabbit SIGLEC7 Polyclonal Antibody | anti-SIGLEC7 antibody

SIGLEC7 Polyclonal Antibody

Cat. Num. AAA2517091

• Gene Names: SIGLEC7; p75; QA79; AIRM1; CD328; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: SIGLEC7; Polyclonal Antibody; SIGLEC7 Polyclonal Antibody; p75; QA79; AIRM1; CD328; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1; anti-SIGLEC7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2.4mg/mL (varies by lot)
• Sequence Length: 145

• Applicable Applications for anti-SIGLEC7 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human SIGLEC7
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using SIGLEC7 Polyclonal Antibody at dilution 1:35)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human brain tissue using SIGLEC7 Polyclonal Antibody at dilution 1:35)

Related Product Information for anti-SIGLEC7 antibody

Siglec-7, which is highly expressed in monocytes and resident blood cells but not in parenchymatous cells, mediates inhibition of natural killer cell cytotoxicity. Due to alternative splicing events, two isoforms exist for Siglec-12, namely SLG-L (the long isoform) and SLG-S (the shorter isoform). These isoforms are differentially expressed with the longer isoform predominantly found in small intestine, spleen and bone marrow, and the shorter isoform predominantly found in small intestine, spleen and adrenal gland.

Product Categories/Family for anti-SIGLEC7 antibody

Stem Cells

NCBI and Uniprot Product Information

• NCBI GI #: 469469047
• NCBI GeneID: 27036
• NCBI Accession #: NP_001264130.1
• NCBI GenBank Nucleotide #: NM_001277201.1
• Molecular Weight: 16,740 Da
• NCBI Official Full Name: sialic acid-binding Ig-like lectin 7 isoform 3
• NCBI Official Synonym Full Names: sialic acid binding Ig-like lectin 7
• NCBI Official Symbol: SIGLEC7
• NCBI Official Synonym Symbols: p75; QA79; AIRM1; CD328; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1
• NCBI Protein Information: sialic acid-binding Ig-like lectin 7; AIRM-1; QA79 membrane protein; adhesion inhibitory receptor molecule 1, siglec-7; sialic acid binding immunoglobulin-like lectin 7
• UniProt Protein Name: Sialic acid-binding Ig-like lectin 7
• Protein Family: Sialic acid-binding Ig-like lectin
• UniProt Gene Name: SIGLEC7
• UniProt Synonym Gene Names: AIRM1; Siglec-7; AIRM-1
• UniProt Entry Name: SIGL7_HUMAN

Uniprot Description

SIGLEC7: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: integral to plasma membrane

Molecular Function: receptor activity; carbohydrate binding

Biological Process: cell adhesion