Rabbit PTPRM Polyclonal Antibody | anti-PTPRM antibody

PTPRM Polyclonal Antibody

Cat. Num. AAA2523578

• Gene Names: PTPRM; RPTPM; RPTPU; PTPRL1; hR-PTPu; R-PTP-MU
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: PTPRM; Polyclonal Antibody; PTPRM Polyclonal Antibody; RPTPM; RPTPU; PTPRL1; hR-PTPu; R-PTP-MU; anti-PTPRM antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.3mg/mL (varies by lot)
• Sequence Length: 1465

• Applicable Applications for anti-PTPRM antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide of human PTPRM
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human breast cancer tissue using PTPRM Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human lung cancer tissue using PTPRM Polyclonal Antibody at dilution 1:40)

Related Product Information for anti-PTPRM antibody

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms.

NCBI and Uniprot Product Information

• NCBI GI #: 156230467
• NCBI GeneID: 5797
• Molecular Weight: 165,060 Da
• NCBI Official Full Name: PTPRM protein
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor type, M
• NCBI Official Symbol: PTPRM
• NCBI Official Synonym Symbols: RPTPM; RPTPU; PTPRL1; hR-PTPu; R-PTP-MU
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase mu; protein tyrosine phosphatase mu; protein tyrosine phosphatase, receptor type, mu polypeptide; protein-tyrosine phosphatase mu
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase mu
• Protein Family: Receptor-type tyrosine-protein phosphatase
• UniProt Gene Name: PTPRM
• UniProt Synonym Gene Names: PTPRL1; Protein-tyrosine phosphatase mu; R-PTP-mu
• UniProt Entry Name: PTPRM_HUMAN

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

PTPRM: a single-pass type I membrane protein involved in cell-cell adhesion through homophilic interactions. A protein-tyrosine phosphatase receptor of the class 2B subfamily. A negative regulator of proliferation and invasion of breast cancer cells. The PTPRM gene is frequently hypermethylated in sporadic cancers. Modulates p120 catenin phosphorylation, promoting adipogenic differentiation. Two isoforms of the human protein have been reported.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine; Membrane protein, integral; Phosphatase

Chromosomal Location of Human Ortholog: 18p11.2

Cellular Component: cell-cell adherens junction; perinuclear region of cytoplasm; lamellipodium; integral to plasma membrane; cytoplasm; intercellular junction

Molecular Function: identical protein binding; protein binding; cadherin binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: response to drug; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; positive regulation of vasodilation; signal transduction; protein amino acid dephosphorylation; homophilic cell adhesion; neurite development; retinal ganglion cell axon guidance