Rabbit PTPN7 Polyclonal Antibody | anti-PTPN7 antibody

PTPN7 Rabbit Polyclonal

Cat. Num. AAA7603173

• Gene Names: PTPN7; LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: PTPN7; Polyclonal Antibody; PTPN7 Rabbit Polyclonal; anti-PTPN7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 359

• Applicable Applications for anti-PTPN7 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Protein tyrosine phosphatase, non-receptor type 7
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human lymphoma using MBS7603173 (PTPN7 antibody) at dilution of 1:100)

Western Blot (WB)

(K-562 cells were subjected to SDS PAGE followed by western blot with MBS7603173 (PTPN7 antibody) at dilution of 1:2000)

NCBI and Uniprot Product Information

• NCBI GI #: 1034560607
• NCBI GeneID: 5778
• NCBI Accession #: XP_016857426.1
• NCBI GenBank Nucleotide #: XM_017001937.1
• Molecular Weight: 52,284 Da
• NCBI Official Full Name: tyrosine-protein phosphatase non-receptor type 7 isoform X6
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, non-receptor type 7
• NCBI Official Symbol: PTPN7
• NCBI Official Synonym Symbols: LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP
• NCBI Protein Information: tyrosine-protein phosphatase non-receptor type 7
• UniProt Protein Name: Tyrosine-protein phosphatase non-receptor type 7
• Protein Family: Tyrosine-protein phosphatase non-receptor
• UniProt Gene Name: PTPN7
• UniProt Synonym Gene Names: HEPTP
• UniProt Entry Name: PTN7_HUMAN

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]

Uniprot Description

HePTP: a non-receptor protein-tyrosine phosphatase. Preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. Its noncatalytic N-terminus can interact with MAP kinases and suppress the MAP kinase activities. Shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Three alternatively spliced transcript variants of this gene, which encode two distinct isoforms, are reported. May play a role in the regulation of lymphocyte development.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: cytoplasm; cytosol; internal side of plasma membrane

Molecular Function: protein binding

Biological Process: protein amino acid dephosphorylation