Typical Testing Data/Standard Curve (for reference only)
Rat CVL (Cytovillin) CLIA Kit | CVL clia kit
Rat CVL (Cytovillin) CLIA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to CVL. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for CVL and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain CVL, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of CVL. You can calculate the concentration of CVL in the samples by comparing the RLU value of the samples to the standard curve.
NCBI and Uniprot Product Information
NCBI Description
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
Ezrin: a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6q25.3
Cellular Component: cortical cytoskeleton; extracellular space; microvillus; basolateral plasma membrane; T-tubule; immunological synapse; cytosol; membrane; perinuclear region of cytoplasm; cytoplasm; apical plasma membrane; nucleolus; uropod; myelin sheath; endosome; vesicle; brush border; filopodium; focal adhesion; actin filament; actin cytoskeleton; ruffle; extrinsic to membrane; cell projection; apical part of cell; microvillus membrane; plasma membrane
Molecular Function: actin filament binding; protein domain specific binding; protein binding; microtubule binding; cell adhesion molecule binding; actin binding; ATPase binding
Biological Process: D-glucose absorption; actin filament bundle formation; axon guidance; filopodium formation; phosphoinositide-mediated signaling; cytoskeletal anchoring; regulation of microvillus length; negative regulation of T cell receptor signaling pathway; establishment of epithelial cell polarity; positive regulation of multicellular organism growth; negative regulation of transcription from RNA polymerase II promoter; microvillus biogenesis; regulation of cell shape; leukocyte adhesion; establishment of centrosome localization; astral microtubule organization and biogenesis; positive regulation of protein secretion; regulation of actin cytoskeleton organization and biogenesis; receptor internalization; membrane to membrane docking; actin cytoskeleton reorganization; gland morphogenesis; regulation of cell size; cortical microtubule organization and biogenesis
Research Articles on CVL
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Product Notes
The Rat CVL ezr (Catalog #AAA2532883) is a CLIA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2532883 CLIA Kit recognizes Rat CVL. It is sometimes possible for the material contained within the vial of "CVL (Cytovillin), CLIA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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