Rabbit anti-Human PTPN2 Polyclonal Antibody | anti-Ptpn2 antibody

PTPN2, CT (PTPN2, PTPT, Tyrosine-protein phosphatase non-receptor type 2, T-cell protein-tyrosine phosphatase)

Cat. Num. AAA6012433

• Gene Names: Ptpn2; Ptpt; TC-PTP; AI325124
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: PTPN2; Polyclonal Antibody; CT (PTPN2; PTPT; Tyrosine-protein phosphatase non-receptor type 2; T-cell protein-tyrosine phosphatase); Anti -PTPN2; anti-Ptpn2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-Ptpn2 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot, Immunohistochemistry, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500; Immunohistochemistry: 1:10-50
• Immunogen: PTPN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 328-358 amino acids from the C-terminal region of human PTPN2.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(PTPN2 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PTPN2 antibody detected the PTPN2 protein (arrow).)

Immunohistochemistry (IHC)

(PTPN2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PTPN2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-Ptpn2 antibody

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported. [provided by RefSeq].

Product Categories/Family for anti-Ptpn2 antibody

Antibodies; Abs to Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 14198420
• NCBI GeneID: 19255
• UniProt Accession #: Q06180; Q3V259; Q922E7
• Molecular Weight: 47,360 Da
• NCBI Official Full Name: Ptpn2 protein
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, non-receptor type 2
• NCBI Official Symbol: Ptpn2
• NCBI Official Synonym Symbols: Ptpt; TC-PTP; AI325124
• NCBI Protein Information: tyrosine-protein phosphatase non-receptor type 2; MPTP; protein-tyrosine phosphatase PTP-2; T cell protein-tyrosine phosphatase
• UniProt Protein Name: Tyrosine-protein phosphatase non-receptor type 2
• Protein Family: Tyrosine-protein phosphatase non-receptor
• UniProt Gene Name: Ptpn2
• UniProt Synonym Gene Names: Ptpt; Protein-tyrosine phosphatase PTP-2
• UniProt Entry Name: PTN2_MOUSE

Uniprot Description

PTPN2: a type 2 non-receptor phospho-tyrosine-protein phosphatase (PTP). Two alternatively spliced isoforms are differenyially expressed. Isoform A is a major PTP expressed in human tissues, while isoform B is expressed mainly in T-cells and in placenta.

Protein type: Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48

Cellular Component: membrane; endoplasmic reticulum; cytoplasm; plasma membrane; ER-Golgi intermediate compartment; nucleus

Molecular Function: integrin binding; protein binding; syntaxin binding; hydrolase activity; phosphoric monoester hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; phosphoprotein phosphatase activity; protein kinase binding

Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of T cell receptor signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of chemotaxis; glucose homeostasis; protein amino acid dephosphorylation; positive regulation of gluconeogenesis; negative regulation of cell proliferation; dephosphorylation; negative regulation of macrophage differentiation; negative regulation of inflammatory response; B cell differentiation; insulin receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat6 protein; negative regulation of tyrosine phosphorylation of Stat3 protein; erythrocyte differentiation; T cell differentiation