Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded rat heart using MBS7603168 (PTPN2 antibody) at dilution of 1:50)
Rabbit anti-Human, Mouse PTPN2 Polyclonal Antibody | anti-PTPN2 antibody
PTPN2 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded rat heart using MBS7603168 (PTPN2 antibody) at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded rat heart using MBS7603168 (PTPN2 antibody) at dilution of 1:50)
Western Blot (WB)
(mouse thymus tissue were subjected to SDS PAGE followed by western blot with MBS7603168 (PTPN2 antibody) at dilution of 1:1000)
Western Blot (WB)
(mouse thymus tissue were subjected to SDS PAGE followed by western blot with MBS7603168 (PTPN2 antibody) at dilution of 1:1000)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
Uniprot Description
PTPN2: a type 2 non-receptor phospho-tyrosine-protein phosphatase (PTP). Two alternatively spliced isoforms are differenyially expressed. Isoform A is a major PTP expressed in human tissues, while isoform B is expressed mainly in T-cells and in placenta.
Protein type: Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 18p11.3-p11.2
Cellular Component: endoplasmic reticulum; ER-Golgi intermediate compartment; nucleoplasm; nucleus; plasma membrane
Molecular Function: integrin binding; non-membrane spanning protein tyrosine phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; syntaxin binding
Biological Process: B cell differentiation; erythrocyte differentiation; glucose homeostasis; insulin receptor signaling pathway; negative regulation of cell proliferation; negative regulation of chemotaxis; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of inflammatory response; negative regulation of insulin receptor signaling pathway; negative regulation of macrophage differentiation; negative regulation of T cell receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat1 protein; negative regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of tyrosine phosphorylation of Stat6 protein; positive regulation of gluconeogenesis; T cell differentiation
Research Articles on PTPN2
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Product Notes
The PTPN2 ptpn2 (Catalog #AAA7603168) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTPN2 Rabbit Polyclonal reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PTPN2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the PTPN2 ptpn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTPN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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