Western Blot (WB)
(Western blot analysis of extracts from various samples, using PTP alpha Antibody.Lane 1: RAW264.7 cells, blocked with antigen-specific peptides,Lane 2: RAW264.7 cells,Lane 3: PC12.)
Rabbit PTP alpha Polyclonal Antibody | anti-PTPalpha antibody
PTP alpha Antibody
Peptide ELISA: 1:20,000-1:40,000
Note: Localizes to focal adhesion sites following integrin engagement.
Western Blot (WB)
(Western blot analysis of extracts from various samples, using PTP alpha Antibody.Lane 1: RAW264.7 cells, blocked with antigen-specific peptides,Lane 2: RAW264.7 cells,Lane 3: PC12.)
Western Blot (WB)
(Western blot analysis of extracts from various samples, using PTP alpha Antibody.Lane 1: RAW264.7 cells, blocked with antigen-specific peptides,Lane 2: RAW264.7 cells,Lane 3: PC12.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
PTPRA: a receptor protein tyrosine phosphatase (PTP). Contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. Dephosphorylates and activates Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Four alternatively spliced isoforms have been reported.
Protein type: Membrane protein, integral; EC 3.1.3.48; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 20p13
Cellular Component: integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: protein binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity
Biological Process: axon guidance; insulin receptor signaling pathway; protein amino acid phosphorylation
Research Articles on PTPalpha
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Product Notes
The PTPalpha ptpra (Catalog #AAA9612563) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTP alpha Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PTP alpha can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Peptide ELISA (EIA). WB: 1:500-1:2000 Peptide ELISA: 1:20,000-1:40,000. Researchers should empirically determine the suitability of the PTPalpha ptpra for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTP alpha, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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