Testing Data
(Gel: 12%SDS-PAGE Lysates (from left to right): Human colon cancer tissue Amount of lysate: 40ug per lane Primary antibody: 1/600 dilution Secondary antibody dilution: 1/8000 Exposure time: 20 seconds)
Rabbit PTN Polyclonal Antibody | anti-PTN antibody
PTN Antibody
Gene Names
PTN; HARP; HBNF; HBGF8; NEGF1
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
Antigen affinity purification.
Synonyms
PTN; Polyclonal Antibody; PTN Antibody; HARP; HBNF; HBGF8; NEGF1; anti-PTN antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total PTN protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
1.2 mg/ml (varies by lot)
Sequence Length
168
Applicable Applications for anti-PTN antibody
Western Blot (WB)
Application Notes
Western blotting: 1:500-1:2000
Immunogen Type
Peptide
Immunogen Description
Synthetic peptide corresponding to a region derived from internal residues of human pleiotrophin
Target Name
PTN
Preparation and Storage
Store at -20 degree C
Testing Data
(Gel: 12%SDS-PAGE Lysates (from left to right): Human colon cancer tissue Amount of lysate: 40ug per lane Primary antibody: 1/600 dilution Secondary antibody dilution: 1/8000 Exposure time: 20 seconds)
Testing Data
(Gel: 12%SDS-PAGE Lysates (from left to right): Human colon cancer tissue Amount of lysate: 40ug per lane Primary antibody: 1/600 dilution Secondary antibody dilution: 1/8000 Exposure time: 20 seconds)
Related Product Information for anti-PTN antibody
Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity regulatory peptide (HARP) or heparin binding growth associated molecule (HB-GAM) is a protein that in humans is encoded by the PTNgene. Pleiotrophin is an 18-kDa growth factor that has a high affinity for heparin. It is structurally related to midkine and retinoic acid induced heparin-binding protein. Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.
Product Categories/Family for anti-PTN antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
18,942 Da
NCBI Official Full Name
pleiotrophin
NCBI Official Synonym Full Names
pleiotrophin
NCBI Official Symbol
PTN
NCBI Official Synonym Symbols
HARP; HBNF; HBGF8; NEGF1
NCBI Protein Information
pleiotrophin
UniProt Protein Name
Pleiotrophin
Protein Family
UniProt Gene Name
PTN
UniProt Synonym Gene Names
HBNF1; NEGF1; PTN; HBBM; HBGF-8; HB-GAM; HBNF-1; OSF-1
UniProt Entry Name
PTN_HUMAN
Uniprot Description
PTN: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation. Belongs to the pleiotrophin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7q33
Cellular Component: extracellular space; endoplasmic reticulum
Molecular Function: heparin binding; growth factor activity; protein phosphatase inhibitor activity
Biological Process: nervous system development; positive regulation of cell division; negative regulation of catalytic activity; positive regulation of cell proliferation; learning; transmembrane receptor protein tyrosine phosphatase signaling pathway; bone mineralization
Research Articles on PTN
1. PTN decreased melanogenesis, probably through MITF degradation via Erk1/2 activation in melanocytes.
Similar Products
Product Notes
The PTN ptn (Catalog #AAA9412053) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTN Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PTN can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:500-1:2000. Researchers should empirically determine the suitability of the PTN ptn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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