Western Blot (WB)
(Mouse Ptk6 Antibody (N-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the Ptk6 antibody detected the Ptk6 protein (arrow).)
Rabbit anti-Human, Mouse Ptk6 Polyclonal Antibody | anti-PTK6 antibody
Ptk6, NT (Ptk6, Sik, Protein-tyrosine kinase 6, SRC-related intestinal kinase)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(Mouse Ptk6 Antibody (N-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the Ptk6 antibody detected the Ptk6 protein (arrow).)
Western Blot (WB)
(Mouse Ptk6 Antibody (N-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the Ptk6 antibody detected the Ptk6 protein (arrow).)
Western Blot (WB)
(Mouse Ptk6 Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Ptk6 antibody detected the Ptk6 protein (arrow).)
Western Blot (WB)
(Mouse Ptk6 Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Ptk6 antibody detected the Ptk6 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Uniprot Description
Brk: a tyrosine kinase of the Src family. May function as an intracellular signal transducer in epithelial tissues. Very high level expression in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. Selectively expressed in breast tumors and cell lines, and perhaps in colon and prostate cancers. Also found in melanocytes. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Overexpression in mammary cells leads to EGF sensitization and results in a partially transformed phenotype. Enhances anchorage-independent growth and responsiveness to EGF. RNAi reduces proliferation in breast cancer cells. Kinase-inactive mutant indicates tumor function may be independent of catalytic function.
Protein type: Protein kinase, TK; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Kinase, protein; TK group; Src family
Chromosomal Location of Human Ortholog: 20q13.3
Cellular Component: nucleoplasm; ruffle; extrinsic to internal side of plasma membrane; cytoplasm; nucleus
Molecular Function: identical protein binding; protein binding; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding
Biological Process: cell migration; protein amino acid autophosphorylation; innate immune response; tyrosine phosphorylation of Stat3 protein; actin cytoskeleton organization and biogenesis; tyrosine phosphorylation of Stat5 protein; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of growth; regulation of cell proliferation
Research Articles on PTK6
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Product Notes
The PTK6 ptk6 (Catalog #AAA6009875) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Ptk6, NT (Ptk6, Sik, Protein-tyrosine kinase 6, SRC-related intestinal kinase) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Ptk6 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the PTK6 ptk6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ptk6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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