Rabbit anti-Human, Mouse PSR Polyclonal Antibody | anti-PSR antibody

PSR antibody

Cat. Num. AAA9411859

• Gene Names: JMJD6; PSR; PTDSR; PTDSR1
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: Purified by antigen-affinity chromatography.
• Synonyms: PSR; Polyclonal Antibody; PSR antibody; anti-PSR antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Purity/Purification: Purified by antigen-affinity chromatography.
• Form/Format: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
• Sequence Length: 403

• Applicable Applications for anti-PSR antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:500-1:3000; Immunohistochemistry: 1:100-1:250
• Immunogen Type: Recombinant protein
• Immunogen Description: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 244 of PSR
• Target Name: PSR
• Preparation and Storage: Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.

Testing Data

(Sample (30 ug of whole cell lysate) A: A431 10% SDS PAGE Primary antibody diluted at 1: 1000)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Cal27 Xenograft, using PSR antibody at 1: 100 dilution.)

Related Product Information for anti-PSR antibody

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Product Categories/Family for anti-PSR antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 125988389
• NCBI GeneID: 23210
• NCBI Accession #: NP_055982
• NCBI GenBank Nucleotide #: NM_015167.2
• Molecular Weight: 47,626 Da
• NCBI Official Full Name: bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform 2
• NCBI Official Synonym Full Names: jumonji domain containing 6
• NCBI Official Symbol: JMJD6
• NCBI Official Synonym Symbols: PSR; PTDSR; PTDSR1
• NCBI Protein Information: bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
• UniProt Protein Name: Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
• Protein Family: Bifunctional arginine demethylase and lysyl-hydroxylase
• UniProt Gene Name: JMJD6
• UniProt Synonym Gene Names: KIAA0585; PTDSR; Protein PTDSR
• UniProt Entry Name: JMJD6_HUMAN

NCBI Description

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

JMJD6: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses. Belongs to the JMJD6 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.-; Nucleolus; Apoptosis; Cell development/differentiation; Oxidoreductase; Receptor, misc.

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: nucleoplasm; nucleolus; plasma membrane; nucleus

Molecular Function: identical protein binding; protein binding; single-stranded RNA binding; histone demethylase activity (H4-R3 specific); RNA binding; iron ion binding; histone demethylase activity (H3-R2 specific); receptor activity

Biological Process: erythrocyte development; transcription, DNA-dependent; heart development; RNA splicing; T cell differentiation in the thymus; recognition of apoptotic cell; peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine; regulation of nuclear mRNA splicing, via spliceosome; macrophage activation; cell surface receptor linked signal transduction; regulation of transcription, DNA-dependent; retina development in camera-type eye; sprouting angiogenesis; kidney development; mRNA processing; lung development