Rabbit anti-Human, Mouse PSMB11 Polyclonal Antibody | anti-PSMB11 antibody

PSMB11 Rabbit Polyclonal

Cat. Num. AAA7603103

• Gene Names: PSMB11; BETA5T
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: PSMB11; Polyclonal Antibody; PSMB11 Rabbit Polyclonal; anti-PSMB11 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 300

• Applicable Applications for anti-PSMB11 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Proteasome (prosome, macropain) subunit, beta type, 11
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(Jurkat cells were subjected to SDS PAGE followed by western blot with MBS7603103 (PSMB11 antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 153791216
• NCBI GeneID: 122706
• NCBI Accession #: NP_001093250.1
• NCBI GenBank Nucleotide #: NM_001099780.1
• Molecular Weight: 32,530 Da
• NCBI Official Full Name: proteasome subunit beta type-11
• NCBI Official Synonym Full Names: proteasome subunit beta 11
• NCBI Official Symbol: PSMB11
• NCBI Official Synonym Symbols: BETA5T
• NCBI Protein Information: proteasome subunit beta type-11
• UniProt Protein Name: Proteasome subunit beta type-11
• Protein Family: Proteasome
• UniProt Gene Name: PSMB11
• UniProt Entry Name: PSB11_HUMAN

NCBI Description

Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008]

Uniprot Description

PSMB11: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome. Plays a pivotal role in development of CD8-positive T cells. Belongs to the peptidase T1B family.

Protein type: EC 3.4.25.1; Proteasome complex; Protease

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: cytosol; nucleus; proteasome core complex

Molecular Function: peptidase activity; threonine endopeptidase activity

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; proteolysis; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway