Rabbit anti-Human, Rat PSAT1 Polyclonal Antibody | anti-PSAT1 antibody

PSAT1 Rabbit Polyclonal

Cat. Num. AAA7603079

• Gene Names: PSAT1; PSA; EPIP; NLS2; PSAT; PSATD
• Reactivity: Human, Rat
• Applications: ELISA, Immunohistochemistry, Western Blot, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: PSAT1; Polyclonal Antibody; PSAT1 Rabbit Polyclonal; anti-PSAT1 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 370

• Applicable Applications for anti-PSAT1 antibody: ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB), Immunoprecipitation (IP)
• Immunogen: Phosphoserine aminotransferase 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse lung using MBS7603079 (PSAT1 antibody) at dilution of 1:100)

Western Blot (WB)

(Hela cells were subjected to SDS PAGE followed by western blot with MBS7603079 (PSAT1 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 17402893
• NCBI GeneID: 29968
• NCBI Accession #: NP_478059.1
• NCBI GenBank Nucleotide #: NM_058179.3
• Molecular Weight: 35,189 Da
• NCBI Official Full Name: phosphoserine aminotransferase isoform 1
• NCBI Official Synonym Full Names: phosphoserine aminotransferase 1
• NCBI Official Symbol: PSAT1
• NCBI Official Synonym Symbols: PSA; EPIP; NLS2; PSAT; PSATD
• NCBI Protein Information: phosphoserine aminotransferase
• UniProt Protein Name: Phosphoserine aminotransferase
• Protein Family: Phosphoserine aminotransferase
• UniProt Gene Name: PSAT1
• UniProt Synonym Gene Names: PSA; PSAT
• UniProt Entry Name: SERC_HUMAN

NCBI Description

This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is a phosphoserine aminotransferase and decreased expression may be associated with schizophrenia. Mutations in this gene are also associated with phosphoserine aminotransferase deficiency. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, and 8. [provided by RefSeq, Jul 2013]

Uniprot Description

PSAT1: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Defects in PSAT1 are the cause of phosphoserine aminotransferase deficiency (PSATD). PSATD is characterized biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.6.1.52; Transferase; Cofactor and Vitamin Metabolism - vitamin B6; Amino Acid Metabolism - glycine, serine and threonine

Chromosomal Location of Human Ortholog: 9q21.2

Cellular Component: cytoplasm; cytosol

Molecular Function: phosphoserine transaminase activity

Biological Process: L-serine biosynthetic process; pyridoxine biosynthetic process

Disease: Neu-laxova Syndrome 2; Phosphoserine Aminotransferase Deficiency