Rabbit anti-Human PRSS8 Polyclonal Antibody | anti-PRSS8 antibody

PRSS8, ID (PRSS8, Prostasin, Serine protease 8, Prostasin light chain, Prostasin heavy chain)

Cat. Num. AAA6011679

• Gene Names: PRSS8; CAP1; PROSTASIN
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: PRSS8; Polyclonal Antibody; ID (PRSS8; Prostasin; Serine protease 8; Prostasin light chain; Prostasin heavy chain); Anti -PRSS8; anti-PRSS8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-PRSS8 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: PRSS8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-219 amino acids from the Central region of human PRSS8.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in MDA-MB453 cell line lysates (35ug/lane) using MBS6011679. This demonstrates that MBS6011679 detected the PRSS8 protein (arrow).)

Related Product Information for anti-PRSS8 antibody

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.

Product Categories/Family for anti-PRSS8 antibody

Antibodies; Abs to Enzymes; Protease (Proteinase; Peptidase)

NCBI and Uniprot Product Information

• NCBI GI #: 4506153
• NCBI GeneID: 5652
• NCBI Accession #: NP_002764.1
• NCBI GenBank Nucleotide #: NM_002773.3
• UniProt Accession #: Q16651; Q9UCA3
• Molecular Weight: 36,431 Da
• NCBI Official Full Name: prostasin preproprotein
• NCBI Official Synonym Full Names: protease, serine, 8
• NCBI Official Symbol: PRSS8
• NCBI Official Synonym Symbols: CAP1; PROSTASIN
• NCBI Protein Information: prostasin; serine protease 8; channel-activating protease 1
• UniProt Protein Name: Prostasin
• Protein Family: Prostasin
• UniProt Gene Name: PRSS8
• UniProt Synonym Gene Names: CAP1
• UniProt Entry Name: PRSS8_HUMAN

NCBI Description

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine. [provided by RefSeq, Jul 2008]

Uniprot Description

PRSS8: Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). Belongs to the peptidase S1 family.

Protein type: EC 3.4.21.-; Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: extracellular space; extracellular region; integral to membrane; plasma membrane

Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: proteolysis