Rabbit anti-Mouse Protein disulfide-isomerase Polyclonal Antibody | anti-PDI antibody

Rabbit anti-mouse Protein disulfide-isomerase polyclonal Antibody

Cat. Num. AAA1489203

• Gene Names: P4hb; PDI; Thbp; ERp59; Pdia1
• Reactivity: Mouse
• Applications: ELISA
• Purity: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Synonyms: Protein disulfide-isomerase; Polyclonal Antibody; Rabbit anti-mouse Protein disulfide-isomerase polyclonal Antibody; Cellular thyroid hormone-binding protein; Endoplasmic reticulum resident protein 59; ER protein 59; ERp59; P4hb; Pdia1; anti-PDI antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Sequence Length: 509

• Applicable Applications for anti-PDI antibody: ELISA (EIA)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: Non-conjugated
• Immunogen: Recombinant mouse Protein disulfide-isomerase protein
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-PDI antibody

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP

NCBI and Uniprot Product Information

• NCBI GI #: 42415475
• NCBI GeneID: 18453
• NCBI Accession #: NP_035162.1
• NCBI GenBank Nucleotide #: NM_011032.2
• UniProt Accession #: P09103; Q922C8
• Molecular Weight: 57,058 Da
• NCBI Official Full Name: protein disulfide-isomerase
• NCBI Official Synonym Full Names: prolyl 4-hydroxylase, beta polypeptide
• NCBI Official Symbol: P4hb
• NCBI Official Synonym Symbols: PDI; Thbp; ERp59; Pdia1
• NCBI Protein Information: protein disulfide-isomerase
• UniProt Protein Name: Protein disulfide-isomerase
• Protein Family: Protein disulfide-isomerase
• UniProt Gene Name: P4hb
• UniProt Synonym Gene Names: Pdia1; PDI; ER protein 59; ERp59
• UniProt Entry Name: PDIA1_MOUSE

Uniprot Description

PDIA1: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Homodimer. Monomers and homotetramers may also occur. Also constitutes the structural subunit of prolyl 4-hydroxylase and of the microsomal triacylglycerol transfer protein MTTP in mammalian cells. Stabilizes both enzymes and retain them in the ER without contributing to the catalytic activity. Binds UBQLN1. Binds to CD4, and upon HIV-1 binding to the cell membrane, is part of a P4HB/PDI-CD4-CXCR4-gp120 complex. Belongs to the protein disulfide isomerase family.

Protein type: Endoplasmic reticulum; Nuclear receptor co-regulator; Isomerase; EC 5.3.4.1; Oxidoreductase

Cellular Component: endoplasmic reticulum; ER-Golgi intermediate compartment; external side of plasma membrane; focal adhesion; membrane; plasma membrane

Molecular Function: enzyme binding; integrin binding; isomerase activity; peptidyl-proline 4-dioxygenase activity; procollagen-proline 4-dioxygenase activity; protein binding; protein disulfide isomerase activity; protein heterodimerization activity

Biological Process: cell redox homeostasis; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; positive regulation of virion penetration into host cell; protein folding