Rabbit anti-Human, Mouse Prostaglandin D Synthase, Lipocalin form Polyclonal Antibody | anti-PTGDS antibody

Prostaglandin D Synthase, Lipocalin form (PGD Synthase, L-PGDS)

Cat. Num. AAA612784

• Gene Names: PTGDS; PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Serum
• Synonyms: Prostaglandin D Synthase; Lipocalin form; Polyclonal Antibody; Lipocalin form (PGD Synthase; L-PGDS); Anti -Prostaglandin D Synthase; anti-PTGDS antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse L-PGDS. Species Crossreactivity: human
• Purity/Purification: Affinity Purified; Serum
• Form/Format: Supplied as a lyophilized powder. Reconstitute with 100ul sterile ddH2O.

• Applicable Applications for anti-PTGDS antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry and Western Blot.; Dilution: Immunohistochemistry: 1:2000; Western Blot: 1:1000 Incubate for 1 hour at RT. Overnight incubations at 4ºC with greater dilutions have also produced optimal results.
• Immunogen: Recombinant mouse lipocalin prostaglandin D synthase (L-PGDS).
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-PTGDS antibody

Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2. PGD2 induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGDS have been identified, namely the lipocalin type enzyme (beta-trace) and the hematopoietic enzyme (1,2). Lipocalin-type PGDS (L-PGDS) is localized in the central nervous system, genital organs of various mammals, and the human heart (1,3-5). Patients with chronic renal failure and hypertension exhibit elevated amounts of L-PGDS in serum and urine (6). The L-PGDS has been identified as beta-trace, which is a major protein in the human cerebrospinal fluid (2,7). Human L-PGDS is a 190 amino acid protein and can be detected at 24-26kD by immunoblotting.

Product Categories/Family for anti-PTGDS antibody

Antibodies; Abs to Prostaglandins

NCBI and Uniprot Product Information

• NCBI GI #: 32171249
• NCBI GeneID: 5730
• NCBI Accession #: NP_000945.3
• NCBI GenBank Nucleotide #: NM_000954.5
• UniProt Accession #: P41222; Q5SQ10; Q7M4P3; Q9UC22; Q9UCC9; Q9UCD9; B2R727
• Molecular Weight: 21,029 Da
• NCBI Official Full Name: prostaglandin-H2 D-isomerase
• NCBI Official Synonym Full Names: prostaglandin D2 synthase 21kDa (brain)
• NCBI Official Symbol: PTGDS
• NCBI Official Synonym Symbols: PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS
• NCBI Protein Information: prostaglandin-H2 D-isomerase; cerebrin-28; PGD2 synthase; beta-trace protein; prostaglandin D synthase; prostaglandin-D2 synthase; glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin D synthase; lipocalin-type prostaglandin-D synthase
• UniProt Protein Name: Prostaglandin-H2 D-isomerase
• Protein Family: Prostaglandin-H2 D-isomerase
• UniProt Gene Name: PTGDS
• UniProt Synonym Gene Names: PDS; PGD2 synthase; PGDS; PGDS2
• UniProt Entry Name: PTGDS_HUMAN

NCBI Description

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

Uniprot Description

PTGDS: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Belongs to the calycin superfamily. Lipocalin family.

Protein type: Secreted; EC 5.3.99.2; Endoplasmic reticulum; Secreted, signal peptide; Isomerase; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 9q34.2-q34.3

Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum membrane; nuclear membrane; rough endoplasmic reticulum; perinuclear region of cytoplasm; extracellular region

Molecular Function: retinoid binding; prostaglandin-D synthase activity; transporter activity; fatty acid binding

Biological Process: transport; response to glucocorticoid stimulus; cyclooxygenase pathway; arachidonic acid metabolic process; prostaglandin biosynthetic process; regulation of circadian sleep/wake cycle, sleep