Testing Data
PCTK2 recombinant protein
PCTK2 (CDK17)/CyclinY, Active
Gene Names
CDK17; PCTK2; PCTAIRE2
Applications
Western Blot
Synonyms
PCTK2; PCTK2 (CDK17)/CyclinY; Active; PCTK2 recombinant protein
Host
Sf9 insect cells using baculovirus
Form/Format
50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Sequence Positions
PCTK2 (CDK17) (Full length) and Cyclin Y (2-end)
Sequence Length
4194
Applicable Applications for PCTK2 recombinant protein
Kinase Assay, Western Blot (WB)
Species
Human
Tag
GST tag
Preparation and Storage
Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Testing Data
Testing Data
Testing Data #2
Testing Data #2
Related Product Information for PCTK2 recombinant protein
Description: Recombinant full-length human PCTK2 (CDK17) and Cyclin Y (2-end) were co-expressed by baculovirus in Sf9 insect cells using N-terminal GST tags.
Scientific Background: PCTK2 (CDK17) or cyclin-dependent kinase 17 belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. PCTK2 has similarity to a rat protein that is thought to play a role in terminally differentiated neurons (1). The identification of a large family of cdc2-related kinases opens the possibility of combinatorial regulation of the cell cycle together with the emerging large family of cyclins (2).
Scientific Background: PCTK2 (CDK17) or cyclin-dependent kinase 17 belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. PCTK2 has similarity to a rat protein that is thought to play a role in terminally differentiated neurons (1). The identification of a large family of cdc2-related kinases opens the possibility of combinatorial regulation of the cell cycle together with the emerging large family of cyclins (2).
Product Categories/Family for PCTK2 recombinant protein
References
1. Hirose T. et.al: PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons. Eur J Biochem. 1997 Oct 15;249 (2):481-8. 2. Meyerson, M.et.al: A family of human cdc2-related protein kinases. EMBO J. 11: 2909-2917, 1992.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
~ 88 kDa; ~ 64 kDa
NCBI Official Full Name
Homo sapiens cyclin dependent kinase 17 (CDK17), transcript variant 1, mRNA
NCBI Official Synonym Full Names
cyclin dependent kinase 17
NCBI Official Symbol
CDK17
NCBI Official Synonym Symbols
PCTK2; PCTAIRE2
NCBI Protein Information
cyclin-dependent kinase 17
UniProt Protein Name
Cyclin-dependent kinase 17
UniProt Gene Name
CDK17
UniProt Synonym Gene Names
PCTAIRE2; PCTK2
NCBI Description
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]
Uniprot Description
CDK17: a CMGC protein kinase of the CDK family. May play a role in terminally differentiated neurons.
Protein type: CDK family; CDK/TAIRE subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); TAIRE subfamily
Chromosomal Location of Human Ortholog: 12q23.1
Cellular Component: cytoplasm; nucleus
Molecular Function: cyclin-dependent protein kinase activity; protein binding; protein kinase activity
Research Articles on PCTK2
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Product Notes
The PCTK2 cdk17 (Catalog #AAA515566) is a Recombinant Protein produced from Sf9 insect cells using baculovirus and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is PCTK2 (CDK17) (Full length) and Cyclin Y (2-end). AAA Biotech's PCTK2 can be used in a range of immunoassay formats including, but not limited to, Kinase Assay, Western Blot (WB). Researchers should empirically determine the suitability of the PCTK2 cdk17 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PCTK2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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