Western Blot (WB)
(Western blot analysis of PCSK2 Antibody (Center) in 293(lane 1), K562(lane 2) cell line lysates (35ug/lane). PCSK2 (arrow) was detected using the purified Pab.)
Rabbit anti-Human Proprotein Convertase 2 Polyclonal Antibody | anti-PC2 antibody
Proprotein Convertase 2 (PC2, KEX2 Like Endoprotease 2, KEX2-like Endoprotease 2, Neuroendocrine Convertase 2, NEC 2, NEC2, Prohormone Convertase 2, Proprotein Convertase Subtilisin/kexin Type 2, PC2, PCSK2, SPC2) (AP)
ELISA: 1:1,000
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of PCSK2 Antibody (Center) in 293(lane 1), K562(lane 2) cell line lysates (35ug/lane). PCSK2 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of PCSK2 Antibody (Center) in 293(lane 1), K562(lane 2) cell line lysates (35ug/lane). PCSK2 (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human brain tissue reacted with PCSK2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human brain tissue reacted with PCSK2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Flow Cytometry (FC/FACS)
(PCSK2 Antibody (Center) flow cytometry analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(PCSK2 Antibody (Center) flow cytometry analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2014]
Uniprot Description
PCSK2: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Belongs to the peptidase S8 family. Furin subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; EC 3.4.21.94
Chromosomal Location of Human Ortholog: 20p11.2
Cellular Component: extracellular space; transport vesicle; membrane; dendrite; perikaryon
Molecular Function: protein binding; serine-type endopeptidase activity; protein complex binding
Biological Process: insulin processing; nervous system development; protein autoprocessing; cellular protein metabolic process; proteolysis
Research Articles on PC2
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Product Notes
The PC2 pcsk2 (Catalog #AAA6494688) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Proprotein Convertase 2 (PC2, KEX2 Like Endoprotease 2, KEX2-like Endoprotease 2, Neuroendocrine Convertase 2, NEC 2, NEC2, Prohormone Convertase 2, Proprotein Convertase Subtilisin/kexin Type 2, PC2, PCSK2, SPC2) (AP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Proprotein Convertase 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:50-1:100 ELISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the PC2 pcsk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Proprotein Convertase 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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