Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using KCNN4 antibody)
Rabbit KCNN4 Polyclonal Antibody | anti-KCNN4 antibody
KCNN4 (Potassium Intermediate/Small Conductance Calcium-activated Channel, Subfamily N, Member 4, IK1, SK4, KCA4, hSK4, IKCA1, hKCa4, KCa3.1, hIKCa1) (APC)
WB: 1:500-1:2000
IHC: 1:50-1:200
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using KCNN4 antibody)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using KCNN4 antibody)
Immunofluorescence (IF)
(Immunofluorescence analysis of HeLa cell using KCNN4 antibody. Blue: DAPI for nuclear staining)
Immunofluorescence (IF)
(Immunofluorescence analysis of HeLa cell using KCNN4 antibody. Blue: DAPI for nuclear staining)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
Uniprot Description
KCNN4: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: voltage-gated potassium channel complex; cell soma; basolateral plasma membrane; apical plasma membrane; plasma membrane; lipid raft
Molecular Function: calmodulin binding; calcium-activated potassium channel activity; protein binding; Intermediate conductance calcium-activated potassium channel activity; small conductance calcium-activated potassium channel activity; protein phosphatase binding
Biological Process: phospholipid translocation; synaptic transmission; positive regulation of T cell receptor signaling pathway; positive regulation of protein secretion; immune system process; calcium ion transport; defense response; cell volume homeostasis; saliva secretion; stabilization of membrane potential; potassium ion transport
Research Articles on KCNN4
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Product Notes
The KCNN4 kcnn4 (Catalog #AAA6423703) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KCNN4 (Potassium Intermediate/Small Conductance Calcium-activated Channel, Subfamily N, Member 4, IK1, SK4, KCA4, hSK4, IKCA1, hKCa4, KCa3.1, hIKCa1) (APC) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's KCNN4 can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC). IF: 1:50-1:200 WB: 1:500-1:2000 IHC: 1:50-1:200 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the KCNN4 kcnn4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KCNN4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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