Testing Data
Rabbit Beta Arrestin-1 Polyclonal Antibody | anti-Arrb1 antibody
Beta Arrestin-1 Antibody
Appearance: Colorless liquid
Shelf Life: 12 months
Testing Data
Testing Data
NCBI and Uniprot Product Information
Uniprot Description
ARRB1: regulates G-protein coupled receptors (GPCR) signaling by mediating both receptor desensitization and resensitization processes. Binds to GRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require receptor determinants exposed only in the active receptor conformation. Targets many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins). Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6). Involved in IL8-mediated granule release in neutrophils. Interacts with phosphorylated ADRB2 and CHRM2. Interacts with SRC (via the SH3 domain and the protein kinase domain); the interaction is independent of the phosphorylation state of SRC C-terminus. Interacts with RAF1, CHUK, IKBKB and Nik. Interacts with DVL1 and DVL2; the interaction is enhanced by DVL phosphorylation. Interacts with IGF1R. Belongs to the arrestin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Cellular Component: basolateral plasma membrane; cytoplasmic membrane-bound vesicle; postsynaptic density; dendritic spine; coated pit; pseudopodium; cytosol; nucleoplasm; postsynaptic membrane; cytoplasm; plasma membrane; intracellular; cytoplasmic vesicle; chromatin; nucleus
Molecular Function: angiotensin receptor binding; protein phosphorylated amino acid binding; clathrin binding; follicle stimulating hormone receptor binding; mitogen-activated protein kinase kinase binding; caspase inhibitor activity; phosphoprotein binding; alpha-1B adrenergic receptor binding; transcription factor binding; GTPase activator activity; alpha-1A adrenergic receptor binding; V2 vasopressin receptor binding; insulin-like growth factor receptor binding; protein binding; histone acetyltransferase activity; G-protein-coupled receptor binding; ubiquitin protein ligase binding; estrogen receptor binding
Biological Process: transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; follicle-stimulating hormone signaling pathway; positive regulation of protein binding; activation of MAPK activity; positive regulation of receptor internalization; positive regulation of caspase activity; protein ubiquitination; negative regulation of caspase activity; sensory perception of pain; protein transport; negative regulation of protein amino acid phosphorylation; sensory perception of touch; phototransduction; negative regulation of interleukin-8 production; negative regulation of interleukin-6 production; regulation of cAMP biosynthetic process; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; positive regulation of Rho protein signal transduction; regulation of cAMP catabolic process; endocytosis; positive regulation of peptidyl-serine phosphorylation; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; G-protein coupled receptor internalization; positive regulation of protein ubiquitination; inhibition of NF-kappaB transcription factor; stress fiber formation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of histone acetylation; negative regulation of protein ubiquitination; positive regulation of protein amino acid phosphorylation; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity
Research Articles on Arrb1
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Product Notes
The Arrb1 arrb1 (Catalog #AAA840235) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Beta Arrestin-1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Beta Arrestin-1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). The antibody can be used in Western Blot analysis (1-4 ug/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately. Expected band ~48 kDa. Researchers should empirically determine the suitability of the Arrb1 arrb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Beta Arrestin-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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