Rabbit anti-Mouse PrLZ Polyclonal Antibody | anti-PrLZ antibody

PrLZ (Protein N8, Tumor Protein D52) (Biotin)

Cat. Num. AAA6458452

• Gene Names: TPD52; D52; N8L; PC-1; PrLZ; hD52
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PrLZ; Polyclonal Antibody; PrLZ (Protein N8; Tumor Protein D52) (Biotin); anti-PrLZ antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse PrLZ. Species Crossreactivity: mouse
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-PrLZ antibody: Western Blot (WB)
• Application Notes: WB: 1:1000; Applications are based on unconjugated antibody.
• Immunogen: KLH conjugated synthetic peptide corresponding to aa100-132 at the Central region of human PrLZ.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Categories/Family for anti-PrLZ antibody

Antibodies; Cancer Markers

NCBI and Uniprot Product Information

• NCBI GI #: 70608172
• NCBI GeneID: 7163
• NCBI Accession #: NP_001020423.1
• NCBI GenBank Nucleotide #: NM_001025252.1
• UniProt Accession #: D0UFD5; P55327
• Molecular Weight: 24,327 Da
• NCBI Official Full Name: tumor protein D52 isoform 1
• NCBI Official Synonym Full Names: tumor protein D52
• NCBI Official Symbol: TPD52
• NCBI Official Synonym Symbols: D52; N8L; PC-1; PrLZ; hD52
• NCBI Protein Information: tumor protein D52; protein N8; prostate leucine zipper; prostate and colon associated protein
• UniProt Protein Name: Tumor protein D52
• UniProt Gene Name: TPD52
• UniProt Entry Name: TPD52_HUMAN

Uniprot Description

TPD52: a coiled-coil motif bearing hydrophilic protein known to be overexpressed in many human solid tumors of diverse cellular origins. May be associated with B cell differentiation. Increased expression is associated with increased proliferation and invasive capacity in different cell types. May negatively regulate ATM protein levels. Isoform 2 is expressed in colon, breast, prostate, pancreas and kidney tumor cell lines. Isoform 2 is expressed at high levels in kidney, prostate, brain, small intestine and pancreas, at moderate levels in placenta and colon, at low levels in lung, liver and heart, and at very low levels in spleen, thymus, peripheral mononuclear blood cells, testis and ovary. Isoform 2 is expressed at lower levels in fetal brain and kidney than in adult brain and kidney. Eight isoforms of the human protein are produced by alternative splicing

Protein type: Endoplasmic reticulum; Calcium-binding

Chromosomal Location of Human Ortholog: 8q21.13

Cellular Component: endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm

Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; calcium ion binding

Biological Process: secretion; anatomical structure morphogenesis; B cell differentiation; positive regulation of cell proliferation