Western Blot (WB)
(Mouse Prkcz Antibody (N-term) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the Prkcz antibody detected the Prkcz protein (arrow).)
Rabbit Prkcz Polyclonal Antibody | anti-Prkcz antibody
Mouse Prkcz Antibody (N-term)
Western Blot (WB)
(Mouse Prkcz Antibody (N-term) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the Prkcz antibody detected the Prkcz protein (arrow).)
Western Blot (WB)
(Mouse Prkcz Antibody (N-term) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the Prkcz antibody detected the Prkcz protein (arrow).)
PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Subunit of a quaternary complex that plays a central role in epithelial cell polarization.
Gao, N., et al. Genes Dev. 24(12):1295-1305(2010)
Yates, L.L., et al. Hum. Mol. Genet. 19(11):2251-2267(2010)
Kim, S., et al. Neuron 66(1):69-84(2010)
de Thonel, A., et al. Mol. Biol. Cell 21(8):1423-1434(2010)
NCBI and Uniprot Product Information
Uniprot Description
PKCZ: an AGC kinase of the PKC family. An atypical PKC: its activity is not regulated by Ca2+, PS, DAG or phorbol esters. Constitutively active.
Protein type: Kinase, protein; EC 2.7.11.13; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Iota subfamily
Cellular Component: tight junction; protein complex; nuclear matrix; intracellular membrane-bound organelle; apical cortex; leading edge; nuclear envelope; intercellular junction; cell cortex; cytosol; lipid raft; axon hillock; filamentous actin; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; plasma membrane; microtubule organizing center; nucleus; cell junction; endosome
Molecular Function: protein domain specific binding; protein kinase C activity; metal ion binding; nucleotide binding; protein kinase binding; protein kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; phospholipase binding; potassium channel regulator activity; transferase activity, transferring phosphorus-containing groups; kinase activity; ATP binding
Biological Process: protein heterooligomerization; membrane hyperpolarization; negative regulation of insulin receptor signaling pathway; signal transduction; protein amino acid phosphorylation; positive regulation of synaptic transmission; activation of NF-kappaB transcription factor; positive regulation of interleukin-4 production; positive regulation of glucose import; cell surface receptor linked signal transduction; positive regulation of T-helper 2 cell differentiation; negative regulation of hydrolase activity; positive regulation of cell proliferation; vesicle transport along microtubule; inflammatory response; positive regulation of cell-matrix adhesion; phospholipase D activation; negative regulation of peptidyl-tyrosine phosphorylation; cell migration; activation of protein kinase B; microtubule cytoskeleton organization and biogenesis; positive regulation of protein transport; membrane depolarization; peptidyl-serine phosphorylation; cellular response to insulin stimulus; long-term memory; establishment of cell polarity; actin cytoskeleton reorganization; insulin receptor signaling pathway; positive regulation of insulin receptor signaling pathway; phosphorylation; negative regulation of protein complex assembly; negative regulation of apoptosis
Research Articles on Prkcz
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Product Notes
The Prkcz prkcz (Catalog #AAA9200917) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-30. The Mouse Prkcz Antibody (N-term) reacts with Mouse (Predicted Reactivity: Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's Prkcz can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Prkcz prkcz for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Prkcz, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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