Western Blot (WB)
(PRCP Antibody (N-term) western blot analysis in MDA-MB231,Hela cell line lysates (35ug/lane).This demonstrates the PRCP antibody detected the PRCP protein (arrow).)
Rabbit anti-Human PRCP Polyclonal Antibody | anti-PRCP antibody
PRCP Antibody (N-term)
Western Blot (WB)
(PRCP Antibody (N-term) western blot analysis in MDA-MB231,Hela cell line lysates (35ug/lane).This demonstrates the PRCP antibody detected the PRCP protein (arrow).)
Western Blot (WB)
(PRCP Antibody (N-term) western blot analysis in MDA-MB231,Hela cell line lysates (35ug/lane).This demonstrates the PRCP antibody detected the PRCP protein (arrow).)
Immunohistochemistry (IHC)
(PRCP Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PRCP Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(PRCP Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PRCP Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
prolylcarboxypeptidase, which cleaves C-terminal amino acids linked
to proline in peptides such as angiotension II, III and
des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the
enzyme activity is retained with some substrates at neutral pH.
This enzyme has been shown to be an activator of the cell
matrix-associated prekallikrein. The importance of angiotension II,
one of the substrates of this enzyme, in regulating blood pressure
and electrolyte balance suggests that this gene may be related to
essential hypertension. Alternatively spliced transcript variants
encoding distinct isoforms have been observed. [provided by
RefSeq].
Zhao, X., et al. Proteomics 10(15):2882-2886(2010)
Abeywickrema, P.D., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 6), 702-705 (2010) :
Soisson, S.M., et al. BMC Struct. Biol. 10, 16 (2010) :
Zhang, Y., et al. Chin. Med. J. 122(20):2461-2465(2009)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Uniprot Description
PRCP: Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. Belongs to the peptidase S28 family.
Protein type: Protease; EC 3.4.16.2
Chromosomal Location of Human Ortholog: 11q14
Cellular Component: lysosome; plasma membrane
Molecular Function: serine carboxypeptidase activity; protein binding
Biological Process: negative regulation of systemic arterial blood pressure; plasma kallikrein-kinin cascade; regulation of blood vessel endothelial cell migration; blood coagulation; glucose homeostasis; proteolysis; angiogenesis involved in wound healing; blood coagulation, intrinsic pathway
Research Articles on PRCP
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Product Notes
The PRCP prcp (Catalog #AAA9203254) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 114-143. The PRCP Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PRCP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the PRCP prcp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PRCP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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